DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3862 and Rcc1

DIOPT Version :9

Sequence 1:	NP_608550.1	Gene:	CG3862 / 33261	FlyBaseID:	FBgn0031286	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001184011.1	Gene:	Rcc1 / 100088	MGIID:	1913989	Length:	434	Species:	Mus musculus

Alignment Length:	478	Identity:	120/478 - (25%)
Similarity:	183/478 - (38%)	Gaps:	100/478 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AKRGVLAQD---KSK----IKEYSPKTTDSH-EHR--------VYVWGFQETGALGLQTNVKKAK 67
            |||....:|   |||    .:...|.|.... .||        |...|..:.|.|||..:|.:.|
Mouse     7 AKRRSPPEDAIPKSKKVKDTRNRGPATRSCQVSHRSHNTEPGLVLTLGQGDVGQLGLGESVLERK 71

  Fly    68 ERYTEMVHHPTRLQFSNNNEITDVAAGYGFTVYAVNRDDGETLFGSGLNTDSQLG--FQVKGNPN 130
            :        |..:..     :.||.......::.|.......::..|.|.:..||  ..|:|:
Mouse    72 K--------PALVPL-----LQDVVQAEAGGMHTVCLSQSGQVYSFGCNDEGALGRDTSVEGS-- 121

  Fly   131 DPANLDVIIYPTAIKLPRVQGETDEDMRVKSMSAGRAHLVVLTQNGTIFTLGN--NSYGQCGRSI 193
                            ..|.|:.:...:|..:|||.:|...||::|.:|..|:  ::.|..|  :
Mouse   122 ----------------EMVPGKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDNNGVIG--L 168

  Fly   194 IEEERYSKSALIHRISQEDICGKEDEVVQVECGQDHSMFLTKKGRIYTCGWGADGQTG------- 251
            :|.   .|.:::....|.|.     .||:|..|.||.:.||..|.:||.|.|..||.|
Mouse   169 LEP---MKKSMVPVQVQLDA-----PVVKVASGNDHLVMLTNDGDLYTLGCGEQGQLGRVPELFA 225

  Fly   252 -QGNYHTAGQITLIGGDVEKEKIVR-------LSCSSDCVLALNEAGDAFGWGNSEYGQLDDSEL 308
             :|.....|::.:....:.|.:..|       ..|.:....|::..|..:|:|.|.|.||.....
Mouse   226 NRGGRQGLGRLLVPRCVLLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGTPGT 290

  Fly   309 AETQI--NIPRALKLTKS-IGKIKDVAAGGSFCMALNDQGLVYTWG---FGILGFGPFVEQTSKP 367
            ....|  |:......||| :|    .:.|....:.::.:|..|:.|   :|.||.|...|:.|
Mouse   291 GSCFIPQNLTSFKNSTKSWVG----FSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKS-- 349

  Fly   368 QHLLPPLFGRNDFSNETTVVSIGCGVFHMGAVNSDGDLFMWGKNRFGHLGLGHKKDQFFPF---- 428
               :|.|..|     ...|.|:.||.....||:.||.:|.||......||.|..:|.:.|.
Mouse   350 ---IPTLISR-----LPVVSSVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMTG 406

  Fly   429 KAAINGKVTKVAYGVDHTIALCK 451
            |...|..|..|:.|..||:.|.|
Mouse   407 KQLENRVVLTVSSGGQHTVLLVK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3862	NP_608550.1	RCC1	43..99	CDD:278826	13/63 (21%)
		RCC1_2	159..188	CDD:290274	10/30 (33%)
		RCC1	175..233	CDD:278826	15/59 (25%)
		RCC1_2	220..249	CDD:290274	13/28 (46%)
		RCC1	236..286	CDD:278826	13/64 (20%)
		RCC1	290..341	CDD:278826	14/53 (26%)
		RCC1	345..395	CDD:278826	16/52 (31%)
		RCC1_2	386..414	CDD:290274	11/27 (41%)
		RCC1	402..449	CDD:278826	17/50 (34%)
Rcc1	NP_001184011.1	RCC1	48..95	CDD:278826	12/59 (20%)
		RCC1	98..147	CDD:278826	13/66 (20%)
		RCC1	150..200	CDD:278826	15/59 (25%)
		RCC1_2	187..216	CDD:290274	13/28 (46%)
		RCC1	203..268	CDD:278826	13/64 (20%)
		RCC1	271..322	CDD:278826	14/54 (26%)
		RCC1	325..368	CDD:278826	16/52 (31%)
		RCC1	376..427	CDD:278826	17/50 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910