Protein Alignment CG3662 and ITM2B

DIOPT Version :10

• Sequence 1: NP_608549.2
• Gene: CG3662 / 33260
• FlyBaseID: FBgn0031285
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_068839.1
• Gene: ITM2B / 9445
• HGNCID: 6174
• Length: 266
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 62/260 - (23%)
• Similarity: 115/260 - (44%)
• Gaps: 37/260 - (14%)

  Fly    25 DEALMHHGSLIAPKVAYSDNEADAESMV---FNRPQHHCIKSFLLFLIAVVVMLLGVLGGWTLYR 86
            ||......:||.|..|.:.:..|.:.:|   ..|....|:...|.|::|.|     :|||..||:
Human    18 DEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGV-----ILGGAYLYK 77

  Fly    87 VYAPSHSSMRYHALCEIPYPEDSMEMARVYPRTVEPFALNWRSLLPELAQPMPNSGSLDESHFRE 151
            .:|.....:.|   |.|.|.:|.:.:..  |....|.|| ::::                   .|
Human    78 YFALQPDDVYY---CGIKYIKDDVILNE--PSADAPAAL-YQTI-------------------EE 117

  Fly   152 DIELDGDSDDEGYARVDVPDFKDGRRGRFMHDFKENQSAIIDTTTGRCFIMPLDRDTTLPPTSFV 216
            :|::..:.:.| :..|.||:|.|......:|||.:..:|.:|....:|:::||:....:||.:.:
Human   118 NIKIFEEEEVE-FISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLL 181

  Fly   217 DLIKKMSTGYYNIDTERVRRQMRVVMPRITDVSLISERIANECFDMKVYMMEK--FVSGVSKRSA 279
            :|:..:..|.|...:..:...| |:..||.::..:...|...|.|.:.|.:::  .:.|:.||.|
Human   182 ELLINIKAGTYLPQSYLIHEHM-VITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGIQKREA 245

  Fly   280  279
            Human   246  245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3662	NP_608549.2	BRICHOS	172..267	CDD:198107	23/94 (24%)
ITM2B	NP_068839.1	Necessary for interaction with APP and inhibitor effects on APP processing	102..134		8/54 (15%)
		BRICHOS	137..231	CDD:198107	23/94 (24%)