| Sequence 1: | NP_001258898.1 | Gene: | HSP90AB1 / 3326 | HGNCID: | 5258 | Length: | 724 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001261362.1 | Gene: | Hsp83 / 38389 | FlyBaseID: | FBgn0001233 | Length: | 717 | Species: | Drosophila melanogaster |
| Alignment Length: | 716 | Identity: | 564/716 - (78%) |
|---|---|---|---|
| Similarity: | 637/716 - (88%) | Gaps: | 2/716 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 10 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKID 74
Human 75 IIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLV 139
Human 140 AEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKK 204
Human 205 HSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEE-DDSGKDKKKK 268
Human 269 TKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL 333
Human 334 FIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQS 398
Human 399 KILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSG 463
Human 464 DEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEF 528
Human 529 DGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVT 593
Human 594 STYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLL 658
Human 659 FETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEV 723
Human 724 D 724 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HSP90AB1 | NP_001258898.1 | Interaction with TP53. /evidence=ECO:0000269|PubMed:15358771 | 2..527 | 412/517 (80%) | |
| Interaction with BIRC2. /evidence=ECO:0000269|PubMed:25486457 | 2..214 | 172/203 (85%) | |||
| Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:P11499 | 9..231 | 185/220 (84%) | |||
| PTZ00272 | 14..724 | CDD:240341 | 559/710 (79%) | ||
| Interaction with AHSA1. /evidence=ECO:0000269|PubMed:25486457 | 215..552 | 260/337 (77%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 222..270 | 27/48 (56%) | |||
| Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:P11499 | 264..608 | 277/343 (81%) | |||
| Interaction with NR1D1. /evidence=ECO:0000250|UniProtKB:P11499 | 620..723 | 72/102 (71%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 696..724 | 9/27 (33%) | |||
| TPR repeat-binding | 720..724 | 3/3 (100%) | |||
| Hsp83 | NP_001261362.1 | PTZ00272 | 6..717 | CDD:240341 | 560/711 (79%) |
| HATPase_c | 28..179 | CDD:214643 | 127/150 (85%) | ||
| HSP90 | 184..706 | CDD:278607 | 398/522 (76%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165147259 | |
| Domainoid | 1 | 1.000 | 826 | 1.000 | Domainoid score | I63 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0326 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H74306 | |
| Inparanoid | 1 | 1.050 | 1149 | 1.000 | Inparanoid score | I211 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG62690 | |
| OrthoDB | 1 | 1.010 | - | - | D174605at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000295 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41993 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100204 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11528 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R576 |
| SonicParanoid | 1 | 1.000 | - | - | X234 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.800 | |||||