DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clp and ZC3H6

DIOPT Version :9

Sequence 1:	NP_477156.1	Gene:	Clp / 33259	FlyBaseID:	FBgn0015621	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_940983.2	Gene:	ZC3H6 / 376940	HGNCID:	24762	Length:	1189	Species:	Homo sapiens

Alignment Length:	266	Identity:	62/266 - (23%)
Similarity:	90/266 - (33%)	Gaps:	101/266 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VCKHWLRGLCKKGDQCEFLHEYDMTKMPE-CYFYSRFNACHNKECPFLHID-PQSKVKDCPWYKR 131
            :||::|.|.|.|||||:|.|:.::.|..| |.||.:......:.|.::|.: |      |.:|..
Human   277 ICKYFLEGRCIKGDQCKFDHDAELEKRKEICKFYLQGYCTKGENCIYMHNEFP------CKFYHS 335

  Fly   132 GF-CRHGPHCRHQH----------LRRVLCMDYL--------------------------AGFCP 159
            |. |..|.:|:..|          |.:||..|..                          .|..|
Human   336 GAKCYQGDNCKFSHDDLTKETKKLLDKVLNTDEELINEDERELEELRKRGITPLPKPPPGVGLLP 400

  Fly   160 EGPSCKHMHPHF------------------ELPPLAELGKDQLHKKLPTCHYCGELGHKANSC-- 204
            ..|.      ||                  ::|.|.|:      ...||.....::|.|..:.
Human   401 TPPE------HFPFSDPEDDFQTDFSDDFRKIPSLFEI------VVKPTVDLAHKIGRKPPAFYT 453

  Fly   205 ------KQYVGSLEHRNNINAMDHSGGHSGG-----YSGHSGHI--EGADDMQSNHHSQPHGPGF 256
                  .|:.||..|..:|    :|.|.|.|     ..|||..:  .|:    ..||.....||
Human   454 SASPPGPQFQGSSPHPQHI----YSSGSSPGPGPNMSQGHSSPVMHPGS----PGHHPCAGPPG- 509

  Fly   257 VKVPTP 262
              :|.|
Human   510 --LPVP 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clp	NP_477156.1	YTH1	12..175	CDD:227416	36/162 (22%)
Clp	NP_477156.1	ZnF_C3H1	66..90	CDD:214632	12/20 (60%)
ZC3H6	NP_940983.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105
		ZnF_C3H1	276..297	CDD:214632	11/19 (58%)
		ZnF_C3H1	303..327	CDD:214632	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..530		19/74 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..659
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..755
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..1026
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1051..1189
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810