DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clp and Cpsf4

DIOPT Version :9

Sequence 1:	NP_477156.1	Gene:	Clp / 33259	FlyBaseID:	FBgn0015621	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_006248931.1	Gene:	Cpsf4 / 304277	RGDID:	620440	Length:	269	Species:	Rattus norvegicus

Alignment Length:	308	Identity:	160/308 - (51%)
Similarity:	194/308 - (62%)	Gaps:	55/308 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDILLANVSGLQFKAERDLIEQVGAIPLPFYGMDKSIAAVCNFITRNGQECDKGSACPFRHIRGD 65
            |..::|:|..::|..|..:.:|:||.||||.|||||.||||.|..:  ..|.||..||||||.|:
  Rat     1 MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLK--AACGKGGMCPFRHISGE 63

  Fly    66 RTIVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSRFNACHNKECPFLHIDPQSKVKDCPWYK 130
            :|:||||||||||||||||||||||||||||||||||:|..|.|||||||||||:||:||||||.
  Rat    64 KTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYD 128

  Fly   131 RGFCRHGPHCRHQHLRRVLCMDYLAGFCPEGPSCKHMHPHFEL-------PPLAEL----GKDQL 184
            ||||:|||.|||:|.|||:|::||.||||||||||.|||.|||       |||.:.    .|...
  Rat   129 RGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPTKQSN 193

  Fly   185 HKKLPTCHYCGELGHKANS-----CKQYVGSLEHRNNINAMDHSGGHSGGYSGHSGHIEGADDMQ 244
            :..|.......:|..:.:|     ..|.:|.::.:|:      |.|:.|
  Rat   194 NPPLQRSSSLIQLTSQNSSPNQQRAPQVIGVMQSQNS------SAGNRG---------------- 236

  Fly   245 SNHHSQPHGPGFVKVPTPLEEITCYKCGNKGHYANKCPKGHLAFLSNQ 292
                           |.|||::||||||.||||||:|.||||||||.|
  Rat   237 ---------------PRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clp	NP_477156.1	YTH1	12..175	CDD:227416	118/169 (70%)
Clp	NP_477156.1	ZnF_C3H1	66..90	CDD:214632	21/23 (91%)
Cpsf4	XP_006248931.1	YTH1	<25..211	CDD:227416	120/187 (64%)
Cpsf4	XP_006248931.1	COG5222	<198..>258	CDD:227547	24/96 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334681
Domainoid	1	1.000	145	1.000	Domainoid score	I4478
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38216
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2398
OMA	1	1.010	-	-		QHG49855
OrthoDB	1	1.010	-	-		D1472764at2759
OrthoFinder	1	1.000	-	-		FOG0002750
OrthoInspector	1	1.000	-	-		oto95475
orthoMCL	1	0.900	-	-		OOG6_103251
Panther	1	1.100	-	-	LDO	PTHR23102
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2133
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770