DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clp and cpsf-4

DIOPT Version :9

Sequence 1:	NP_477156.1	Gene:	Clp / 33259	FlyBaseID:	FBgn0015621	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	NP_001023126.1	Gene:	cpsf-4 / 178151	WormBaseID:	WBGene00044329	Length:	302	Species:	Caenorhabditis elegans

Alignment Length:	297	Identity:	138/297 - (46%)
Similarity:	177/297 - (59%)	Gaps:	42/297 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDILLANVSGLQFKAERDLIEQVGAIPLPFYGMDKSIAAVCNFITRNG-QECDKGSACPFRHIRG 64
            |..|::|::......|..|..|.|....||..:|:|..|||.   :|. :.|..|..||.|||.|
Worm    15 MTDLVSNITAPMTDVEEALFNQRGMKEAPFRDLDRSGKAVCR---KNKLKMCPFGPTCPLRHIDG 76

  Fly    65 DRTIVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSRFNACHNKECPFLHIDPQSKVKDCPWY 129
            ::.:|||||||||||||||||||||||:||||||:|:|:::||.|:||||.||||::|:||||||
Worm    77 EKAVVCKHWLRGLCKKGDQCEFLHEYDLTKMPECFFFSKYSACSNRECPFRHIDPETKMKDCPWY 141

  Fly   130 KRGFCRHGPHCRHQHLRRVLCMDYLAGFCPEGPSCKHMHPHFELPPLAELGKDQ---LHKKLPTC 191
            .||||||||:|:|:|.||.:|.:||||||.:||.|::.||.|.||....:....   .:.:..||
Worm   142 DRGFCRHGPYCKHRHRRRAVCPNYLAGFCLQGPDCQYAHPSFGLPSFENIAVSHAKPTYSQAITC 206

  Fly   192 HYCGELGHKANSCKQYVGSLEHRNNINAMDHSGGHSGGYSGHSGHIEGADDMQSNHHSQPHGPGF 256
            |.|.|.||||.:|.                              |:.|......:||   |....
Worm   207 HNCHERGHKATTCP------------------------------HLPGQTRQNQDHH---HRVDL 238

  Fly   257 VKVPTP--LEEITCYKCGNKGHYANKCPKGHLAFLSN 291
            ..:|..  |.::||||||.||||||:|.||.||||||
Worm   239 SLIPDKKNLSDVTCYKCGEKGHYANRCHKGALAFLSN 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clp	NP_477156.1	YTH1	12..175	CDD:227416	96/163 (59%)
Clp	NP_477156.1	ZnF_C3H1	66..90	CDD:214632	20/23 (87%)
cpsf-4	NP_001023126.1	YTH1	<66..187	CDD:227416	83/120 (69%)
		ZnF_C3H1	77..102	CDD:214632	20/24 (83%)
		ZnF_C3H1	133..158	CDD:214632	18/24 (75%)
		ZnF_C3H1	157..181	CDD:214632	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38216
Inparanoid	1	1.050	291	1.000	Inparanoid score	I1688
Isobase	1	0.950	-	0	Normalized mean entropy	S731
OMA	1	1.010	-	-		QHG49855
OrthoDB	1	1.010	-	-		D1472764at2759
OrthoFinder	1	1.000	-	-		FOG0002750
OrthoInspector	1	1.000	-	-		oto20411
orthoMCL	1	0.900	-	-		OOG6_103251
Panther	1	1.100	-	-	LDO	PTHR23102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2013
SonicParanoid	1	1.000	-	-		X2133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820