DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Clp and CPSF4

DIOPT Version :9

Sequence 1:	NP_477156.1	Gene:	Clp / 33259	FlyBaseID:	FBgn0015621	Length:	296	Species:	Drosophila melanogaster
Sequence 2:	XP_011514057.1	Gene:	CPSF4 / 10898	HGNCID:	2327	Length:	274	Species:	Homo sapiens

Alignment Length:	313	Identity:	159/313 - (50%)
Similarity:	193/313 - (61%)	Gaps:	60/313 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDILLANVSGLQFKAERDLIEQVGAIPLPFYGMDKSIAAVCNFITRNGQECDKGSACPFRHIRGD 65
            |..::|:|..::|..|..:.:|:||.||||.|||||.||||.|..:  ..|.||..||||||.|:
Human     1 MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLK--AACGKGGMCPFRHISGE 63

  Fly    66 RTIVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSRFNACHNKECPFLHIDPQSKVKDCPWYK 130
            :|:||||||||||||||||||||||||||||||||||:|..|.|||||||||||:||:||||||.
Human    64 KTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYD 128

  Fly   131 RGFCRHGPHCRHQHLRRVLCMDYLAGFCPEGPSCKHMH-----PHFEL-------PPLAEL---- 179
            ||||:|||.|||:|.|||:|::||.||||||||||.|.     |.|||       |||.:.
Human   129 RGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMQLLVTSPRFELPMGTTEQPPLPQQTQPP 193

  Fly   180 GKDQLHKKLPTCHYCGELGHKANS-----CKQYVGSLEHRNNINAMDHSGGHSGGYSGHSGHIEG 239
            .|...:..|.......:|..:.:|     ..|.:|.::.:|:      |.|:.|
Human   194 AKQSNNPPLQRSSSLIQLTSQNSSPNQQRTPQVIGVMQSQNS------SAGNRG----------- 241

  Fly   240 ADDMQSNHHSQPHGPGFVKVPTPLEEITCYKCGNKGHYANKCPKGHLAFLSNQ 292
                                |.|||::||||||.||||||:|.||||||||.|
Human   242 --------------------PRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Clp	NP_477156.1	YTH1	12..175	CDD:227416	117/174 (67%)
Clp	NP_477156.1	ZnF_C3H1	66..90	CDD:214632	21/23 (91%)
CPSF4	XP_011514057.1	YTH1	<25..>161	CDD:227416	104/137 (76%)
CPSF4	XP_011514057.1	COG5222	<231..>263	CDD:227547	20/68 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141015
Domainoid	1	1.000	145	1.000	Domainoid score	I4607
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38216
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2488
Isobase	1	0.950	-	0	Normalized mean entropy	S731
OMA	1	1.010	-	-		QHG49855
OrthoDB	1	1.010	-	-		D1472764at2759
OrthoFinder	1	1.000	-	-		FOG0002750
OrthoInspector	1	1.000	-	-		oto88328
orthoMCL	1	0.900	-	-		OOG6_103251
Panther	1	1.100	-	-	LDO	PTHR23102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2013
SonicParanoid	1	1.000	-	-		X2133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750