DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PGAP2 and CWH43

DIOPT Version :9

Sequence 1:	NP_608548.1	Gene:	PGAP2 / 33258	FlyBaseID:	FBgn0031284	Length:	255	Species:	Drosophila melanogaster
Sequence 2:	NP_009943.2	Gene:	CWH43 / 850376	SGDID:	S000000610	Length:	953	Species:	Saccharomyces cerevisiae

Alignment Length:	239	Identity:	60/239 - (25%)
Similarity:	112/239 - (46%)	Gaps:	50/239 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LPFARLALVALSLPLGGFFFCVI--WSLTFDFV--RSTYTHCDVTNYLPSVSAAIGNYEPQKTVW 78
            :|.|. .:.|.|    .||..::  :||.|..:  .:.||:.|  .:.|||||.||:..|:::::
Yeast     9 IPIAH-TICAFS----AFFAALVTGYSLHFHKIVTNAHYTYPD--EWFPSVSATIGDRYPERSIF 66

  Fly    79 RLAIFLHLPLRLAVAKIYLEHYREHIRRSRRLLGILACFL-NVVEDLALFCLSFWTSADHYETHR 142
            ::.|.|....|..   :.|.||  ::.:|:      .||| .|:..::.....:.||.|.::.|.
Yeast    67 QILIALTAFPRFL---LLLGHY--YLNQSK------VCFLVGVLRTVSCGGWVYITSTDDHDIHD 120

  Fly   143 NAFVVFIACSECYMLVSYLLNRNIQKTVLLPHEEKSLRY-----KRNLFLVNVIAFGLAG---YC 199
                :|        :::|::       :.||.:....||     .:|..|...|.||...   |.
Yeast   121 ----IF--------MITYIV-------LTLPWDIMITRYSSPLTSKNKGLTATIFFGTLFPMIYW 166

  Fly   200 FVRHNSHCEAGVYTFFALFEYIVVLTNMGFHMTSYWDFYALNVV 243
            :::|:....||.|:.:|.||:.::|.::.|...:|.||..:::|
Yeast   167 YIQHSVQQRAGAYSIYAYFEWSLILLDIAFDAFAYADFKKIDIV 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PGAP2	NP_608548.1	Frag1	19..240	CDD:287278	59/233 (25%)
CWH43	NP_009943.2	Frag1	5..207	CDD:402067	59/234 (25%)
CWH43	NP_009943.2	Exo_endo_phos	701..911	CDD:397447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I2895
eggNOG	1	0.900	-	-		E1_KOG3979
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99160
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R277
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930