DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex12 and PEX12

DIOPT Version :9

Sequence 1:	NP_001259844.1	Gene:	Pex12 / 33256	FlyBaseID:	FBgn0031282	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_013739.1	Gene:	PEX12 / 855041	SGDID:	S000004628	Length:	399	Species:	Saccharomyces cerevisiae

Alignment Length:	353	Identity:	75/353 - (21%)
Similarity:	132/353 - (37%)	Gaps:	95/353 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PSIFEISASETLDNLIYPALSKIFDYFGLRLDFKLWGSLRIQE---ELSPLLTWLLQYLYLRKRA 76
            |:||||.:|:.:|:|: ||..:......|..:|....:||:.:   |....:...:::.:|:...
Yeast    32 PTIFEIMSSQEIDSLL-PASIRYLLANHLVANFPNRYTLRLNKYFFEWFQAIKGFVEWYHLKTYN 95

  Fly    77 SSFGESFYGLQ------RTVTTT-------------GDLLNRRQQFASATLLTFMPYVERKL--- 119
            |:|.:.|||||      |.:..|             |..||::|:.........:||:..||
Yeast    96 STFIDRFYGLQLFSSRDRNLALTQCLNPKGQSEWPQGLQLNQQQKSVIFLEKIILPYITAKLDEI 160

  Fly   120 ------RTRITRHEDTSPWEQRLLSAFHAFHAAKAAHT--------------------FFYLVKY 158
                  ....:..|..:.|.:|.....:.|.....|.:                    :.:.::|
Yeast   161 LEKISMNNIFSSDETENKWPKRAFLRIYPFIKKLLALSNLLVKLLFLTKRTGSVSLLQYLFKIEY 225

  Fly   159 A------------------------SNHSPIFRL----LGLTLRYPSEPPKEDQWTYVVLKMLEV 195
            .                        :|.|.||.|    |.:..|:         .|::..:....
Yeast   226 TTVRPLSSELSGLKETKGMDNRLRKTNISSIFALMQGQLSIIPRF---------LTFMGSQFFPT 281

  Fly   196 LAFFLQFVQWWYSNDQRRKVGGTLIN-PEAMPRKQLPKEVQQSLPQRG---ECPVCLLSIQTPTA 256
            ..|.|:..|||.:.|...|:...:.: .|.:||........::..:.|   .||||..::|.|..
Yeast   282 FIFVLRVYQWWTTQDMTTKLQKRVNDLDEDIPRPPFSSHSDKTEDKEGVSEACPVCEKTVQNPCV 346

  Fly   257 CSVSGYVFCWKCIVSHM-KEHGTCPVTH 283
            .. :|||.|:.|.:|:: ...|.||||:
Yeast   347 LE-TGYVACYPCAISYLVNNEGHCPVTN 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex12	NP_001259844.1	Pex2_Pex12	24..209	CDD:282595	46/263 (17%)
Pex12	NP_001259844.1	zf-RING_2	242..281	CDD:290367	15/42 (36%)
PEX12	NP_013739.1	Pex2_Pex12	41..295	CDD:398431	46/263 (17%)
PEX12	NP_013739.1	mRING_PEX12	334..375	CDD:319365	17/41 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342121
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0826
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	52	1.000	Inparanoid score	I1828
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55389
OrthoFinder	1	1.000	-	-		FOG0005079
OrthoInspector	1	1.000	-	-		oto99985
orthoMCL	1	0.900	-	-		OOG6_103569
Panther	1	1.100	-	-	LDO	PTHR12888
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R900
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790