DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex12 and PEX12

DIOPT Version :9

Sequence 1:	NP_001259844.1	Gene:	Pex12 / 33256	FlyBaseID:	FBgn0031282	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_000277.1	Gene:	PEX12 / 5193	HGNCID:	8854	Length:	359	Species:	Homo sapiens

Alignment Length:	380	Identity:	107/380 - (28%)
Similarity:	168/380 - (44%)	Gaps:	110/380 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAE------AANVRQNLQNVPSIFEISASETLDNLIYPALSKIF--------DYFGLRLDFKLWG 51
            |||      ||:|   ..:.|||||:.|.::|...:.|||..:.        .::|.     ||
Human     1 MAEHGAHFTAASV---ADDQPSIFEVVAQDSLMTAVRPALQHVVKVLAESNPTHYGF-----LW- 56

  Fly    52 SLRIQEELSPLLTWLLQYLYLRKRASSFGESFYGLQRTVTTTGDLLNRRQQFASATL-------- 108
              |..:|:..||..|||..||.:.::||.|:||||:|.|  .|| .::.|:.|||.|
Human    57 --RWFDEIFTLLDLLLQQHYLSRTSASFSENFYGLKRIV--MGD-THKSQRLASAGLPKQQLWKS 116

  Fly   109 ---LTFMPYVERKLRTRIT--RHED-------TSPWEQRLLSAFHAFHAAKAAHTFF-------- 153
               |..:||::.||...::  |.||       :|.|::       .:.|..||:.|.
Human   117 IMFLVLLPYLKVKLEKLVSSLREEDEYSIHPPSSRWKR-------FYRAFLAAYPFVNMAWEGWF 174

  Fly   154 ------YLVKYASNHSPIFRLLGLTL---------RYPSEPPKEDQWTY---------------- 187
                  |::..|.:|||:.||.|:.|         ....:|.|......
Human   175 LVQQLRYILGKAQHHSPLLRLAGVQLGRLTVQDIQALEHKPAKASMMQQPARSVSEKINSALKKA 239

  Fly   188 ---VVLKM---LEVLAFFLQFVQWWYSNDQRRKVGGTLINPEAMPRKQLPKEVQQS-----LPQ- 240
               |.|.:   |.|..|||||:.||||::.:.    |:.:..|:|....|..:..:     ||:
Human   240 VGGVALSLSTGLSVGVFFLQFLDWWYSSENQE----TIKSLTALPTPPPPVHLDYNSDSPLLPKM 300

  Fly   241 RGECPVCLLSIQTPTACSVSGYVFCWKCIVSHMKEHGTCPVTHYPISLDDLVRIY 295
            :..||:|..:....|..:.||||||::|:..:::.|..||:|.||..:..|:::|
Human   301 KTVCPLCRKTRVNDTVLATSGYVFCYRCVFHYVRSHQACPITGYPTEVQHLIKLY 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex12	NP_001259844.1	Pex2_Pex12	24..209	CDD:282595	69/257 (27%)
Pex12	NP_001259844.1	zf-RING_2	242..281	CDD:290367	13/38 (34%)
PEX12	NP_000277.1	Pex2_Pex12	26..267	CDD:282595	69/258 (27%)
PEX12	NP_000277.1	RING	304..341	CDD:214546	13/36 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143585
Domainoid	1	1.000	59	1.000	Domainoid score	I10745
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H240
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4805
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55389
OrthoDB	1	1.010	-	-		D1204472at2759
OrthoFinder	1	1.000	-	-		FOG0005079
OrthoInspector	1	1.000	-	-		oto90835
orthoMCL	1	0.900	-	-		OOG6_103569
Panther	1	1.100	-	-	LDO	PTHR12888
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R900
SonicParanoid	1	1.000	-	-		X5424
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900