DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex12 and SPAPB17E12.03

DIOPT Version :9

Sequence 1:	NP_001259844.1	Gene:	Pex12 / 33256	FlyBaseID:	FBgn0031282	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001342998.1	Gene:	SPAPB17E12.03 / 3361409	PomBaseID:	SPAPB17E12.03	Length:	343	Species:	Schizosaccharomyces pombe

Alignment Length:	334	Identity:	77/334 - (23%)
Similarity:	127/334 - (38%)	Gaps:	66/334 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PSIFEISASETLDNLIYPALSKIFDYFGLRLDFKLWGSLRIQEELSPLLTWLLQYLYLRKRASSF 79
            ||:.|:...:.::.||.|:|..|..||..|....|..:....:.:..|:..||:...|:|..::.
pombe     4 PSLLEVLQVQQVEKLISPSLRFILAYFTHRYPRFLLRAYNSFDGIYLLVKLLLEKSQLKKWNATS 68

  Fly    80 GESFYGLQRTVTTTGDLLNRR---QQFASAT-----------LLTF-MPYVERKLRTRITRHED- 128
            .|..:.|:|.:......:...   |:..|||           .||: :||:..|..:..|..|:
pombe    69 VERRFQLKRVIAVRDSSIIAEEFPQESESATSLNGIDVLKKLFLTYCIPYLLEKCESLTTVKENH 133

  Fly   129 ---------TSPWEQRLLSAFHA----------------FHAAKAAHTF---FYLVKYASNHSPI 165
                     ....::..||.|::                |...:.::|:   .|.:.||...:|.
pombe   134 TAVSILSLQARDKQKGALSVFYSKIKILLVRLKKILHFVFRLIRKSNTYLQWLYYLLYALGKTPY 198

  Fly   166 FRLLGLTLRYP--------------SEPPKEDQWTYVVLKMLEVLAFFLQFVQWWYSN--DQRRK 214
            ..|....||..              |...|....|.:....:|.....:|.:.||.||  :...|
pombe   199 TNLADHILRQRVIYNVENIHSRKLISTREKSSLLTSIADHSMEGFLIIIQLIDWWQSNNYESHLK 263

  Fly   215 VGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTPTACSVSGYVFCWKCIVSHMKEHG-T 278
            .|.......|.|:  ||.|:..|...  .|.:|...|:.|...| :|:|||:.||...::.|. .
pombe   264 KGEVAFTELAPPK--LPFEINVSTTD--ICKICGEKIKNPAVLS-TGFVFCYPCIQVWLQRHPFK 323

  Fly   279 CPVTHYPIS 287
            ||||:..:|
pombe   324 CPVTNLELS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex12	NP_001259844.1	Pex2_Pex12	24..209	CDD:282595	47/242 (19%)
Pex12	NP_001259844.1	zf-RING_2	242..281	CDD:290367	13/39 (33%)
SPAPB17E12.03	NP_001342998.1	Pex2_Pex12	13..256	CDD:309754	47/242 (19%)
		mRING_PEX12	289..329	CDD:319365	16/40 (40%)
		modified RING finger	289..327	CDD:319365	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0826
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H240
Inparanoid	1	1.050	54	1.000	Inparanoid score	I2041
OMA	1	1.010	-	-		QHG55389
OrthoFinder	1	1.000	-	-		FOG0005079
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103569
Panther	1	1.100	-	-	LDO	PTHR12888
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R900
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860