DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex12 and Pex12

DIOPT Version :9

Sequence 1:	NP_001259844.1	Gene:	Pex12 / 33256	FlyBaseID:	FBgn0031282	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001351691.1	Gene:	Pex12 / 103737	MGIID:	2144177	Length:	359	Species:	Mus musculus

Alignment Length:	359	Identity:	96/359 - (26%)
Similarity:	148/359 - (41%)	Gaps:	99/359 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PSIFEISASETLDNLIYPALSKIFD--------YFGLRLDFKLWGSLRIQEELSPLLTWLLQYLY 71
            |||||:.|.::|...:.|||..:..        ::|.     ||   |..:|:..||.:|||..|
Mouse    18 PSIFEVVAQDSLMTAVRPALQHVVKVLAESNPAHYGF-----LW---RWFDEIFTLLDFLLQQHY 74

  Fly    72 LRKRASSFGESFYGLQRTVTTTGDLLNR--------RQQFASATLLTFMPYVERKLRTRIT--RH 126
            |.:.::||.|.||||:|.|..:...|.|        ...:.||..|..:||::.||....:  |.
Mouse    75 LSRTSASFSEHFYGLKRIVAGSSPHLQRPASAGLPKEHLWKSAMFLVLLPYLKVKLEKLASSLRE 139

  Fly   127 ED-------TSPWEQRLLSAFHAFHAAKAAHTFF--------------YLVKYASNHSPIFRLLG 170
            ||       :|.|::       .:.|..||:.|.              |::..|.:|||:.:|.|
Mouse   140 EDEYSIHPPSSRWKR-------FYRAFLAAYPFVNMAWEGWFLTQQLRYILGKAEHHSPLLKLAG 197

  Fly   171 LTL-------------------------RYPSEPPKEDQWTYVVLKM------------LEVLAF 198
            :.|                         |...|..|.      .||.            |.|..|
Mouse   198 VRLARLTAQDMQAIKQRLVEASAMQEPVRSVGEKIKS------ALKKAVGGVALSLSTGLSVGVF 256

  Fly   199 FLQFVQWWYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSL--PQRGECPVCLLSIQTPTACSVSG 261
            ||||:.||||::.:..:......|...|...|.......|  ..:..||:|..:....|..:.||
Mouse   257 FLQFLDWWYSSENQEAIKSLTALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKTRVNDTVLATSG 321

  Fly   262 YVFCWKCIVSHMKEHGTCPVTHYPISLDDLVRIY 295
            ||||::|:.::::.|..||:|.||..:..|:::|
Mouse   322 YVFCYRCVFNYVRSHQACPITGYPTEVQHLIKLY 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex12	NP_001259844.1	Pex2_Pex12	24..209	CDD:282595	66/260 (25%)
Pex12	NP_001259844.1	zf-RING_2	242..281	CDD:290367	13/38 (34%)
Pex12	NP_001351691.1	Pex2_Pex12	26..267	CDD:368100	78/318 (25%)
		mRING_PEX12	304..345	CDD:319365
		modified RING finger	304..342	CDD:319365

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833740
Domainoid	1	1.000	58	1.000	Domainoid score	I10796
eggNOG	1	0.900	-	-		E1_KOG0826
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H240
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4813
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55389
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005079
OrthoInspector	1	1.000	-	-		oto94418
orthoMCL	1	0.900	-	-		OOG6_103569
Panther	1	1.100	-	-	LDO	PTHR12888
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R900
SonicParanoid	1	1.000	-	-		X5424
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790