DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Saf6 and Taf6l

DIOPT Version :9

Sequence 1:	NP_608545.1	Gene:	Saf6 / 33255	FlyBaseID:	FBgn0031281	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001101045.1	Gene:	Taf6l / 309194	RGDID:	1310123	Length:	623	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	132/661 - (19%)
Similarity:	215/661 - (32%)	Gaps:	195/661 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 HGLAGGIAGAEASGNSSRMGHQKSYAGFDPRSIKIFWEQHDQTDVELSQDVCARLAEDASYKVWE 165
            |...|.::..|          ::.:......|:::..|   .|.:|||.:|.|.||||..|::.|
  Rat     2 HSSTGAMSERE----------ERRFVEIPRESVRLMAE---STGLELSDEVAALLAEDVCYRLRE 53

  Fly   166 LINNVKIYSRHS-GGVVTYDLVNEVLKDADVPPMLGAMDSDW--DRIDYDGSFYFHSDK---IFE 224
            ...|...:.:|: ...:|.:..|..|:.:.|..:.|....:.  .|...:|..||..|:   :.|
  Rat    54 ATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEVLPLRPAREGELYFPEDREVNLVE 118

  Fly   225 LS---------AEFQKEVNLCTPDD----ADFQSICPVEDKHMDQLRQCVQSLVTAALFADSKSQ 276
            |:         ||....|::...|.    |...|:........|.|.:..|. ||.|:..|....
  Rat   119 LALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYQQ-VTRAVLGDDPQL 182

  Fly   277 TAAVCHAFQTPLMGSIYRVIVSKMVQLLAF--------KQQDHLSQRCWRLLRACNYNATANHNA 333
            ........||.          ||:..||.:        |...|..::..|||:... :...|.:.
  Rat   183 MKVALQDLQTN----------SKIAALLPYFVYVVSGVKSVSHDLEQLHRLLQVAR-SLIRNPHL 236

  Fly   334 CRPEYFNLAEVLVSQLMAPYETIKA------------------------PHVDPDPGQTTSIKME 374
            |...|  :..::.|.|....|.:.|                        .|.|...|....|.:.
  Rat   237 CLGPY--VRSLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQQILLS 299

  Fly   375 FEEELKVEPDQCHNPETQENPEVMGVEKQEQEPQMFPGESTMEHTIYKLQSEEEELNPQPEAEHL 439
            .::.| .:|.:   |.......|:|:...        |...:|..:|               .||
  Rat   300 LQKVL-TDPVR---PLCSHYGAVVGLHAL--------GWKAVERVLY---------------PHL 337

  Fly   440 SSYFACPVGN--GLVDELCETIGQLASQSGYLHAECLFLIKRRLARFFEGRHVSSERDFRYISRA 502
            .:|:.    |  .::|:...:..|:.:....::...|..::|.|....:....:
  Rat   338 PTYWT----NLQAVLDDYSVSNAQVKADGHKVYGAILVAVERLLKMKAQAAEPN----------- 387

  Fly   503 VRGLIALGEYAFR--EFIPYIYKLRVEEIPDSLWPD-------LAPAAIFLGGHD-------DVY 551
             ||  .||...:|  |.:|: ..|.::|.|.....:       |.|:.: .|..|       |:|
  Rat   388 -RG--GLGGRGYRPAEDLPW-DSLLLQESPPGGGSEPGFGSGLLLPSGV-AGSEDPSSLTLADIY 447

  Fly   552 --LYEWL------EYGCGAALQPFLVHYARAYEKMVTRRYVKAKQPAYRIESVPGVRRLEWS--- 605
              ||.:.      .:|.|   ||         .....|.....|:||...:||..:.:|..|
  Rat   448 RELYSFFGDSLATRFGTG---QP---------APTAPRPPGDKKEPATTPDSVRKMPQLTASAVV 500

  Fly   606 -----------TLAAAMCHGDDPSKALKPKPTLCEAFPDLQSPNLQLNCAGNIRFKFAGCRPVLL 659
                       |||||  :....|:.| |:.......|..|.|.             ||.|.|..
  Rat   501 SPQGDESPCGGTLAAA--NATSESRPL-PRVHRARGAPRQQGPG-------------AGTRDVFQ 549

  Fly   660 KPKVAT--VPH 668
            |.:.|.  .||
  Rat   550 KSRFAPRGAPH 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Saf6	NP_608545.1	None
Taf6l	NP_001101045.1	TAF	16..80	CDD:281032	18/66 (27%)
		TAF6C	160..372	CDD:381749	44/256 (17%)
		HEAT repeat	162..193	CDD:381749	8/31 (26%)
		HEAT repeat	200..232	CDD:381749	6/32 (19%)
		HEAT repeat	242..285	CDD:381749	4/42 (10%)
		HEAT repeat	292..324	CDD:381749	6/35 (17%)
		HEAT repeat	326..371	CDD:381749	8/63 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10221
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100