Protein Alignment Dbp21E2 and Ddx28

DIOPT Version :10

• Sequence 1: NP_608544.1
• Gene: Dbp21E2 / 33254
• FlyBaseID: FBgn0086130
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_082314.2
• Gene: Ddx28 / 71986
• MGIID: 1919236
• Length: 540
• Species: Mus musculus
• Alignment Length: 562
• Identity: 177/562 - (31%)
• Similarity: 284/562 - (50%)
• Gaps: 74/562 - (13%)

  Fly     1 MLNLSVVLRVQSSRHVASYATAAAAAVKTKPPKAKSKGKKQK---------------GEPLISCR 50
            :|.|:|.|.::..|::....:..:..| .:.|:|..:.::|:               |..|:|.|
Mouse     9 LLALAVRLLLEPRRNLVVRGSDQSLPV-VRVPRALQRRQEQRQSGRGSLQRPVLVRPGPLLVSAR 72

  Fly    51 RSQFD------LTQYEQTDAKFGSLSLASKGWLHNKSKGDFFILNASVRGEELQQEMQTVDEFLE 109
            |.:.:      |.::|:.       .|||:||.|.:|:.|.|.:      |.:|||...:.. |.
Mouse    73 RPELNQPARLTLGRWERA-------PLASRGWKHRRSRQDHFSI------ERVQQEAPALRN-LS 123

  Fly   110 STG----MQIHPQLLENLRVEL-GIKLLTGIQKQGMPVVHGNEHCLIAAETGCGKTITYLLPIVD 169
            |.|    :.:.|::|..|:..: .:...|.:|.:.:|.:....|.|.|||||.|||::||||:..
Mouse   124 SRGSFVDLGLEPRVLLALQEAVPEVVQPTSVQSKTIPPLLRGRHLLCAAETGSGKTLSYLLPLFQ 188

  Fly   170 KLLQKEVVTERKLNTPRVLILTPGRELATQIAGVTEKLTQGTNLKVQSLLGG----NTK-QLMMN 229
            :||:...:..|....||.|:|.|.||||.|:..|.:.|.....|:|..|.||    ..| ||...
Mouse   189 RLLRGSDLDSRSFTAPRGLVLVPSRELAEQVQAVAQSLGGYLGLQVIELGGGLGMSRLKLQLYRR 253

  Fly   230 PQFEEVDILVATLGALSKLVTTGIYRMEQVRHLVLDEADTLLDDTFTDKLSYFLRRFPF-----H 289
            |   ..|:||||.|||.|.:.:.:..::.:..:||||.|||||::|.:.:.|.|.:.|.     .
Mouse   254 P---AADVLVATPGALWKALKSQLISLQHLNFIVLDEVDTLLDESFLELVDYILEKSPIAESPAE 315

  Fly   290 LVQKEDAGTQMILASATMPTNTREILHKVIDVDTIREVVSPHLHRLMSHVTQKFLRLSKADRPAT 354
            |....:...|::|..||.|....::|.||...|::..:.|..||.||.||.|.|:||..||:...
Mouse   316 LEDPFNPKAQLVLVGATFPEGLNQLLSKVTSPDSLTTITSSKLHCLMPHVRQTFMRLKGADKVTE 380

  Fly   355 LLSLVKHD--LAKRRP---LIVFSNKSTTSDFVSIFLNNSGVNCLNLNGDMLMKIRLGRFEQFQN 414
            |:.::|..  .:|..|   ::||.|.::|.:::...|::..:..|.|.|.|...:|.|.|:.||.
Mouse   381 LVQILKQQDKASKTEPSGTVLVFCNSASTVNWLGYILDDHKIQHLRLQGQMPASMRAGIFQSFQK 445

  Fly   415 GHCDVLSTTDVGSRGLDTTRARHVVNFDFPLHVSDYIHRCGRIGRVGNMDKALVTNLISSRREID 479
            |..::|..||:.|||||:.....|:|:|||..:.|||||.||:||||:.....|.:.::...::.
Mouse   446 GSQNILVCTDIASRGLDSVHVEVVINYDFPPTLQDYIHRAGRVGRVGSEVPGSVISFVTHPWDVS 510

  Fly   480 VVQRIEHAARTGGLLPDVNANIRNIINKRIVAEMKAAGMPVP 521
            :||:||.|||....||.:.:::               |.|:|
Mouse   511 LVQKIELAARRRRSLPGLASSV---------------GDPLP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbp21E2	NP_608544.1	DEADc_DDX28	119..345	CDD:350706	84/236 (36%)
		SF2_C_DEAD	339..462	CDD:350174	49/127 (39%)
Ddx28	NP_082314.2	Mitochondrial targeting signal. /evidence=ECO:0000255	3..18		4/8 (50%)
		Q motif	126..156		5/29 (17%)
		DEAD-like_helicase_N	137..371	CDD:475120	84/236 (36%)
		Nuclear export signal. /evidence=ECO:0000255	180..191		4/10 (40%)
		DEAD	286..289		2/2 (100%)
		SF2_C_DEAD	365..503	CDD:350174	51/137 (37%)
		Nuclear localization signal. /evidence=ECO:0000255	520..523		1/2 (50%)