DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and PRKX

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_005035.1	Gene:	PRKX / 5613	HGNCID:	9441	Length:	358	Species:	Homo sapiens

Alignment Length:	336	Identity:	143/336 - (42%)
Similarity:	202/336 - (60%)	Gaps:	21/336 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 ESRKLAMKQAQESCRDEP-----KEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVK---AHHQD 480
            :|||:    |:|:....|     .|.|..|.|...|.|.:.::|:|.|.||||.|||   |.|
Human    15 DSRKV----AEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKH-- 73

  Fly   481 RVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIW 545
               .||||.:....::..|||:|:.:|:.::.....||:.||:.|:.||:::|||:|...|||::
Human    74 ---FFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELF 135

  Fly   546 TMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTS 610
            :.||:||.|......|....::.|.||||::.|:||||||||::||..|::|:.||||||::  .
Human   136 SYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL--V 198

  Fly   611 SKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMI 675
            .:|||.||||||:|||:|.:|||.||||:|||||||.|:|:|.|||...:|...|..||.|  .|
Human   199 DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG--KI 261

  Fly   676 AFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAH 740
            .||:|:......|||:|.....:.|||....|..|:|.|:||...||:.:..:.|.||.|..||.
Human   262 DFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVDWEAVPQRKLKPPIVPKIAG 326

  Fly   741 PTDVRYFDRFP 751
            ..|...|:.:|
Human   327 DGDTSNFETYP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736
		CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		Pkinase	457..717	CDD:278497	118/262 (45%)
		STKc_cGK	463..724	CDD:270724	121/263 (46%)
		S_TK_X	719..>760	CDD:214529	11/33 (33%)
PRKX	NP_005035.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		6/22 (27%)
		PTZ00263	39..358	CDD:140289	135/308 (44%)
		STKc_PRKX_like	47..338	CDD:270763	132/300 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910