DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and pnpla6

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_005160109.1	Gene:	pnpla6 / 560986	ZFINID:	ZDB-GENE-050107-4	Length:	1343	Species:	Danio rerio

Alignment Length:	446	Identity:	95/446 - (21%)
Similarity:	166/446 - (37%)	Gaps:	75/446 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EAIVSNLTKDVQALREMVRSRESELVKLH-----------REIHKLKSVLQQTTNNLNVTRNEKA 65
            |....:|.:.||.:  |||.:...::.||           .|:....|.|.......:..|:.|.
Zfish   281 EKYPESLVRVVQII--MVRLQRVTVLALHNYLGLTNELFSHEMQPRSSPLSPHPTRSSPVRHSKR 343

  Fly    66 KKKLYSLPEQCGEQESRNQNPHLCSSCGMVLPT-SPEFALEALSLGPLSPLAST-SSASPSGR-- 126
            ...| ::|::..|...:|.........|..:|| |...::.....|....|.|. ..|...||
Zfish   344 FGSL-TVPDKHREAAVQNATGGDHGKEGGTIPTLSRTISMPVDIAGMQKSLRSDFDMAYERGRIS 407

  Fly   127 TSADEVRPKAMPAAIKKQGVSAESCVQSMQQSYSIPIPKYEKD-FSDKQQIKDAIMDNDFLKNI- 189
            .||::    .:||..|:|.....:..:.....|..|..:...| ||..|...:|.:..:..|.|
Zfish   408 VSAED----GVPAFTKEQRERKVTVDEVPSGVYLYPEEESGMDIFSSFQGRPNATVFEEAQKEIL 468

  Fly   190 ------DASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGA---- 244
                  |.|.:...|...::|   ||..:.|:|:....|:...:|...|.|  |::||..|
Zfish   469 RLMKIEDPSLLNGRVTFHHAK---AGSVLARQGDQDVSLHFVLSGCLHVYQ--KMIDKQEAVCLF 528

  Fly   245 ----GKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLL 305
                |:..|:||:|.......:|:...:...: .:.:..|.:||      |.:.||....:..:.
Zfish   529 VTQPGEMVGQLAVLTGEPLIFTIKAERDCTFL-KISKSEFYEIM------REQPSVVLSAAHTVA 586

  Fly   306 MNLSEELLAKIADVLELEF------YAAGTYIIRQGTAGDSFFLISQGNVR-VTQKLTPTSPEET 363
            :.:|       |.|.:::|      ..||..:.||....|..:::..|.:| |.:|   .:.::.
Zfish   587 IRMS-------AFVRQMDFAIDWMAVEAGRALYRQDDQSDCTYIVLNGRLRSVIRK---ANGKKE 641

  Fly   364 ELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEK 419
            .:....|||..|....:....|...:.|:.        |.:..|...|.|..:|.:
Zfish   642 LVGEYGRGDLIGVVEALTRQPRATTVHAVR--------DTELVKLPEGTLNNIKRR 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	47/224 (21%)
		CAP_ED	185..285	CDD:237999	26/114 (23%)
		CAP_ED	304..419	CDD:237999	24/121 (20%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
pnpla6	XP_005160109.1	TM_EGFR-like	31..64	CDD:213052
		Crp	164..>302	CDD:223736	7/22 (32%)
		CAP_ED	170..291	CDD:237999	2/9 (22%)
		Crp	466..>596	CDD:223736	32/148 (22%)
		CAP_ED	467..577	CDD:237999	27/121 (22%)
		CAP_ED	590..698	CDD:237999	24/118 (20%)
		Crp	605..>706	CDD:223736	20/96 (21%)
		Pat_PNPLA6_PNPLA7	921..1226	CDD:132864
		RssA	926..1216	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900