DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and PRKG1

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_006249.1	Gene:	PRKG1 / 5592	HGNCID:	9414	Length:	686	Species:	Homo sapiens

Alignment Length:	762	Identity:	372/762 - (48%)
Similarity:	489/762 - (64%)	Gaps:	96/762 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 REREAIVSNLTKDVQALREMVRSRESELV-KLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSL 72
            |:|:|::..|        |:...::.||: ||..|:.|.:||::..|
Human    19 RQRDALIDEL--------ELELDQKDELIQKLQNELDKYRSVIRPAT------------------ 57

  Fly    73 PEQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAM 137
                  |:::.|:                              |||....|  ||
Human    58 ------QQAQKQS------------------------------ASTLQGEP--RT---------- 74

  Fly   138 PAAIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMY 202
                |:|.:|||.....:|....:.:|.|.|....|..||:||:||||:||::.||::|:||.||
Human    75 ----KRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMY 135

  Fly   203 SKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLS 267
            .........:|:||:||:.:||...|:..|.::|..|..||.||.||||||||||||||:::.|.
Human   136 PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLV 200

  Fly   268 EAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYII 332
            . .::|.:||:.||.|||.|||.:....:.||:|||...:|.||:|:|:|||||...|..|.|||
Human   201 N-VKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYII 264

  Fly   333 RQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVE 397
            |||..||:||:||:|.|.||::.:| |.:...||||.:||:|||:||..||.||||:|| :..|.
Human   265 RQGARGDTFFIISKGTVNVTREDSP-SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA-AEAVT 327

  Fly   398 CLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVST 462
            ||.:||||||.|||.|.::..|.|.|...| |..:|:.:.           |.:|||:|..::.|
Human   328 CLVIDRDSFKHLIGGLDDVSNKAYEDAEAK-AKYEAEAAF-----------FANLKLSDFNIIDT 380

  Fly   463 LGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFR 527
            ||:|||||||||:...::. ..||:|.|||||||||:|:|||.||:.||..:.|.||.||||||:
Human   381 LGVGGFGRVELVQLKSEES-KTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFK 444

  Fly   528 DEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDE 592
            |.||:|||:|||:|||:||:|||||||||:..:|...||::||.|||::||||||||||||:||.
Human   445 DSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDH 509

  Fly   593 RGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFS 657
            |||.|:|||||||:||...|||||||||||||||||||||||.:.|||:||||::|||.|:||||
Human   510 RGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS 574

  Fly   658 APDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDW 722
            .||||:|||:||:|||||.|||.|::.|..|||:||||.||||||....|::||:|||||.||:|
Human   575 GPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNW 639

  Fly   723 DGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNE-PPDELSGWDADF 768
            :||....|.||.:..:|.|||...||.||.|.:| |||:.||||.||
Human   640 EGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	101/202 (50%)
		CAP_ED	185..285	CDD:237999	46/99 (46%)
		CAP_ED	304..419	CDD:237999	62/114 (54%)
		Pkinase	457..717	CDD:278497	175/259 (68%)
		STKc_cGK	463..724	CDD:270724	179/260 (69%)
		S_TK_X	719..>760	CDD:214529	20/41 (49%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	13/43 (30%)
		CAP_ED	118..227	CDD:237999	51/109 (47%)
		CAP_ED	237..341	CDD:237999	59/105 (56%)
		STKc_cGK	381..641	CDD:270724	179/260 (69%)
		S_TK_X	636..>679	CDD:214529	21/42 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57714
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2508
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.760