Protein Alignment Pkg21D and PRKCZ

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: XP_016857278.1
• Gene: PRKCZ / 5590
• HGNCID: 9412
• Length: 603
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 106/338 - (31%)
• Similarity: 178/338 - (52%)
• Gaps: 42/338 - (12%)

  Fly   421 YGDESRKLAMKQAQESCRDEPKE-----------QLQQEFPDLKLTDLEVVSTLGIGGFGRVELV 474
            |...|||      .:|.:|:.::           ::.|   .|.|.|.:::..:|.|.:.:|.||
Human   214 YISSSRK------HDSIKDDSEDLKPVIDGMDGIKISQ---GLGLQDFDLIRVIGRGSYAKVLLV 269

  Fly   475 KAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIM-LSSRSPFICRLYRTFRDEK-------- 530
            :....|:  |:|:|.:||..:.|.:..:.:.:|:|:. .:|.:||:..|:..|:...
Human   270 RLKKNDQ--IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLRRLSPC 332

  Fly   531 YVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGY 595
            .:::::|...||::...::.:....:..|:|....:..|..:||.|||||||||.:|::||..|:
Human   333 RLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGH 397

  Fly   596 VKIVDFGFAKQ-IGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSA- 658
            :|:.|:|..|: :|....|.||||||.|:||||:..:.:..:||:||||:|:.|::.|..||..
Human   398 IKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII 462

  Fly   659 ---PDPMQTYNLILKGI--DMIAFPKHISRWAVQLIKRLCRDVPSERLGY--QTGGIQDIKKHKW 716
               || |.|.:.:.:.|  ..|..|:.:|..|..::|......|.||||.  || |..|||.|.:
Human   463 TDNPD-MNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQT-GFSDIKSHAF 525

  Fly   717 FLGFDWDGLASQL 729
            |...|||.:..||
Human   526 FRSIDWDLMHRQL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		STKc_cGK	463..724	CDD:270724	93/278 (33%)
		S_TK_X	719..>760	CDD:214529	5/11 (45%)
PRKCZ	XP_016857278.1	PB1_aPKC	16..98	CDD:99725
		C1	129..183	CDD:412127
		Protein Kinases, catalytic domain	236..537	CDD:473864	98/307 (32%)