DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and PRKAR2B

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_002727.2	Gene:	PRKAR2B / 5577	HGNCID:	9392	Length:	418	Species:	Homo sapiens

Alignment Length:	364	Identity:	106/364 - (29%)
Similarity:	173/364 - (47%)	Gaps:	48/364 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 FALEALSLGPLSPLASTSSAS--------PSGRTSADEVRPKAMPA--------AIKKQGVSAES 150
            |..|..:.|.|...|...:.|        |....|.|....:|.||        .|.:....|..
Human    51 FGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASV 115

  Fly   151 CVQSMQQSYSIPIPKYEKDFSD-----------KQQIKDAIMDNDFLKNIDASQVRELVDSMYSK 204
            |.::..       |..|:|.::           :.::::|..|....||:|..|:.:::|:|:.|
Human   116 CAEAYN-------PDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEK 173

  Fly   205 SIAAGEFVIREGEVGAHLYVSAAGEFAVMQQ----GKVLDKMGAGKAFGELAILYNCTRTASIRV 265
            .:..||.||.:|:.|.:.||...|.|.:..:    |:.:.......:|||||::||..|.|:|..
Human   174 LVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITA 238

  Fly   266 LSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNL--SEELLAKIADVLELEFYAAG 328
            .|..| :|.|||..|::|::....::.:...:|:.|:|.|.:|  ||.|  |:.||:..:.|..|
Human   239 TSPGA-LWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERL--KVVDVIGTKVYNDG 300

  Fly   329 TYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEE----TELRTLSRGDYFGEQALINEDKRTANI 389
            ..||.||.:.||||::..|.|::|.|....|..|    .|:...|||.||||.||:....|.|:.
Human   301 EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASA 365

  Fly   390 IALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKL 428
            .|:.. |:||.:|..:|:||:|...|:.:::......:|
Human   366 HAIGT-VKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	73/212 (34%)
		CAP_ED	185..285	CDD:237999	36/103 (35%)
		CAP_ED	304..419	CDD:237999	46/120 (38%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
PRKAR2B	NP_002727.2	Dimerization and phosphorylation	2..153		20/108 (19%)
		DD_RIIbeta_PKA	3..43	CDD:213051
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..96		10/44 (23%)
		Crp	150..>259	CDD:223736	37/109 (34%)
		CAP_ED	154..267	CDD:237999	36/113 (32%)
		Crp	270..>385	CDD:223736	46/117 (39%)
		CAP_ED	276..396	CDD:237999	46/122 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810