DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and PRKAR2A

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001308911.1	Gene:	PRKAR2A / 5576	HGNCID:	9391	Length:	404	Species:	Homo sapiens

Alignment Length:	370	Identity:	101/370 - (27%)
Similarity:	176/370 - (47%)	Gaps:	45/370 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PTSPEFALEALS--LGPLSPLASTSSASPSGRTSADEVRPKAMPAAIKKQGVSAESCVQSMQQSY 159
            |...|||:|..:  ....:|.:...:|:|  |.|.....|:..|..:......:||   ...:..
Human    27 PDLVEFAVEYFTRLREARAPASVLPAATP--RQSLGHPPPEPGPDRVADAKGDSES---EEDEDL 86

  Fly   160 SIPIPK------------YEKD-------------FSDKQ--QIKDAIMDNDFLKNIDASQVREL 197
            .:|:|.            |..|             .:|:|  ::::|..|....||:|..|:.::
Human    87 EVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQV 151

  Fly   198 VDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVM----QQGKVLDKMGAGKAFGELAILYNCT 258
            :|:|:.:.:.|.|.||.:|:.|.:.||...|.:.::    .|.:.:.:.....:|||||::||..
Human   152 LDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTP 216

  Fly   259 RTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELE 323
            |.|:|...||.: :|.|||..|::|::....::.:...:|:.|||||.:|......||.||:..:
Human   217 RAATIVATSEGS-LWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEK 280

  Fly   324 FYAAGTYIIRQGTAGDSFFLISQGNVRV-----TQKLTPTSPEETELRTLSRGDYFGEQALINED 383
            .|..|..||.||...|||::|..|.|.:     |:.......:|.|:....:|.||||.||:...
Human   281 IYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNK 345

  Fly   384 KRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKL 428
            .|.|:..|:. .|:||.:|..:|:||:|...::.:::......:|
Human   346 PRAASAYAVG-DVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQL 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	67/211 (32%)
		CAP_ED	185..285	CDD:237999	34/103 (33%)
		CAP_ED	304..419	CDD:237999	40/119 (34%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
PRKAR2A	NP_001308911.1	Dimerization and phosphorylation	2..138		22/115 (19%)
		DD_RIIalpha_PKA	4..44	CDD:213050	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..90		8/47 (17%)
		Crp	135..>244	CDD:223736	35/109 (32%)
		CAP_ED	139..251	CDD:237999	34/112 (30%)
		Crp	255..>371	CDD:223736	42/116 (36%)
		CAP_ED	261..382	CDD:237999	40/121 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810