DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and PRKAR1A

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001263218.1	Gene:	PRKAR1A / 5573	HGNCID:	9388	Length:	381	Species:	Homo sapiens

Alignment Length:	405	Identity:	108/405 - (26%)
Similarity:	191/405 - (47%)	Gaps:	50/405 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ALREMVRS-RESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLPEQCGEQESRNQNPH 87
            |..|..|| ||.|   |:.:.|.::::|:.:...|...|.|:....|....|:..::|::.
Human     7 AASEEARSLRECE---LYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQ---- 64

  Fly    88 LCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAMPAAIK----KQGVSA 148
                                       :.:...|.....:..||:.|......:|    :..:||
Human    65 ---------------------------IQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISA 102

  Fly   149 ESCVQSMQQSY---SIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGE 210
            |...:....||   .||     ||:.....:..||..|....::|.::..::.|:|:|.|..|||
Human   103 EVYTEEDAASYVRKVIP-----KDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGE 162

  Fly   211 FVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVL 275
            .||::|:.|.:.||...||..|....:....:|.|.:|||||::|...|.|:::..:. .::|.:
Human   163 TVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTN-VKLWGI 226

  Fly   276 DRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDS 340
            ||..:::|:|.:.|::.:....||..|.:|.:|.:.....:||.||...:..|..|:.||..||.
Human   227 DRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDE 291

  Fly   341 FFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDS 405
            ||:|.:|:..|.|:.: .:.|..|:..|...|||||.||:....|.|.::|..| ::|:.|||..
Human   292 FFIILEGSAAVLQRRS-ENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGP-LKCVKLDRPR 354

  Fly   406 FKRLIGDLCELKEKD 420
            |:|::|...::.:::
Human   355 FERVLGPCSDILKRN 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	65/202 (32%)
		CAP_ED	185..285	CDD:237999	31/99 (31%)
		CAP_ED	304..419	CDD:237999	39/114 (34%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
PRKAR1A	NP_001263218.1	Dimerization and phosphorylation	1..136		32/167 (19%)
		DD_RIalpha_PKA	14..63	CDD:213048	13/51 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		5/62 (8%)
		Pseudophosphorylation motif	96..100		0/3 (0%)
		CAP_ED	137..246	CDD:237999	33/109 (30%)
		CAP_ED	255..370	CDD:237999	39/117 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810