Protein Alignment Pkg21D and PRKACG

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 123/293 - (41%)
• Similarity: 187/293 - (63%)
• Gaps: 6/293 - (2%)

  Fly   458 EVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRL 522
            |.:.|||:|.||||.||:  ||:....:|:|.|.|:.:|..||.|||.:|:.|:.:...||:.:|
Human    45 ERLRTLGMGSFGRVMLVR--HQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKL 107

  Fly   523 YRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPEN 587
            ..:|:|..|:|:::|...|||:::.|:..|.|.:..|.|....|:.|.:|||:..:|:|||||||
Human   108 QFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPEN 172

  Fly   588 LMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNG 652
            |::|::||:::.||||||::  ..:|||.||||||:||||||:||:::|||:||||:||:|:..|
Human   173 LLIDQQGYLQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVG 235

  Fly   653 TPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF 717
            .|||.|..|:|.|..|:.|  .:.||..:|.....|::.|.:...::|.|....|:.|||.||||
Human   236 FPPFYADQPIQIYEKIVSG--RVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWF 298

  Fly   718 LGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRF 750
            ....|..:..:.:..||:.....|.|...||.:
Human   299 ATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDY 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		STKc_cGK	463..724	CDD:270724	115/260 (44%)
		S_TK_X	719..>760	CDD:214529	7/32 (22%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	123/291 (42%)