DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and PRKACB

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_891993.1	Gene:	PRKACB / 5567	HGNCID:	9381	Length:	398	Species:	Homo sapiens

Alignment Length:	328	Identity:	134/328 - (40%)
Similarity:	195/328 - (59%)	Gaps:	9/328 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 DESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFAL 487
            |.|.|..:.:|:|....:.:...|.   :..|.|.|...|||.|.||||.|||  |:.....:|:
Human    60 DRSMKEFLAKAKEDFLKKWENPTQN---NAGLEDFERKKTLGTGSFGRVMLVK--HKATEQYYAM 119

  Fly   488 KCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRG 552
            |.|.|:.:|..||.||..:|:.|:.:...||:.||...|:|...:||::|...|||:::.||..|
Human   120 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIG 184

  Fly   553 SFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFC 617
            .|.:..|:|....::..|||||:..:||||||||||::|.:||:::.||||||::  ..:|||.|
Human   185 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLC 247

  Fly   618 GTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHIS 682
            |||||:||||||:||:::|||:||||:||:|:..|.|||.|..|:|.|..|:.|  .:.||.|.|
Human   248 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFS 310

  Fly   683 RWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYF 747
            .....|::.|.:...::|.|....|:.|||.||||...||..:..:.:..||:.......|...|
Human   311 SDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF 375

  Fly   748 DRF 750
            |.:
Human   376 DDY 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736
		CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		Pkinase	457..717	CDD:278497	117/259 (45%)
		STKc_cGK	463..724	CDD:270724	119/260 (46%)
		S_TK_X	719..>760	CDD:214529	7/32 (22%)
PRKACB	NP_891993.1	STKc_PKA	89..378	CDD:271111	127/294 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840