DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and prkar1ab

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001017732.1	Gene:	prkar1ab / 550427	ZFINID:	ZDB-GENE-050417-238	Length:	379	Species:	Danio rerio

Alignment Length:	426	Identity:	108/426 - (25%)
Similarity:	194/426 - (45%)	Gaps:	65/426 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAGMLTDREREAIVSNLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNVTRNEKA 65
            ||:|.::..|.:::                 ||.|   ::.:.|.::.:|:.....|..:|.::.
Zfish     1 MASGSVSSEEEKSL-----------------RECE---VYVQKHNVQQLLKDCIVQLCTSRPDRP 45

  Fly    66 KKKLYSLPEQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSAD 130
            ...|....|:..::||:.                               |.:...||....:..|
Zfish    46 MAFLREYFERLEKEESKQ-------------------------------LLNQQKASSRSDSRED 79

  Fly   131 EVRPKAMPAA---IKKQGVSAESCVQSMQQSY---SIPIPKYEKDFSDKQQIKDAIMDNDFLKNI 189
            ||.|...|..   .::..:|||...:....||   .||     ||:.....:..||..|....::
Zfish    80 EVSPPMNPVVKGRRRRGAISAEVYTEEDAASYVRKVIP-----KDYKTMAALAKAIEKNVLFSHL 139

  Fly   190 DASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAIL 254
            |.::..::.|:|:..:..|||.||::|:.|.:.||...||..|....:....:|.|.:|||||::
Zfish   140 DDNERSDIFDAMFPVTYIAGEIVIQQGDEGDNFYVIDQGEMDVYVNSEWATSIGEGGSFGELALI 204

  Fly   255 YNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADV 319
            |...|.|::|..:. .::|.:||..:::|:|.:.|::.:....||..|.:|.:|.:.....:||.
Zfish   205 YGTPRAATVRAKTN-VKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADA 268

  Fly   320 LELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDK 384
            ||...:.....|:.||..||.||:|.:|...|.|:.: .:.|..|:..|...|||||.||:....
Zfish   269 LEPVQFEDSQKIVVQGEPGDEFFIILEGCAAVLQRRS-ENEEFVEVGRLGPSDYFGEIALLMNRP 332

  Fly   385 RTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKD 420
            |.|.::|..| ::|:.|||..|:|::|...::.:::
Zfish   333 RAATVVARGP-LKCVKLDRPRFERVLGPCSDILKRN 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	63/202 (31%)
		CAP_ED	185..285	CDD:237999	30/99 (30%)
		CAP_ED	304..419	CDD:237999	38/114 (33%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
prkar1ab	NP_001017732.1	DD_RIalpha_PKA	13..62	CDD:213048	10/68 (15%)
		Crp	129..>255	CDD:223736	38/126 (30%)
		CAP_ED	135..244	CDD:237999	32/109 (29%)
		Crp	247..>357	CDD:223736	40/111 (36%)
		CAP_ED	253..368	CDD:237999	38/117 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910