DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and prkaca

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_012808518.1	Gene:	prkaca / 549157	XenbaseID:	XB-GENE-5954970	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	400	Identity:	150/400 - (37%)
Similarity:	220/400 - (55%)	Gaps:	43/400 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 QKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVE--CLTLDRDSFKRLIGDLCE 415
            |||     |....|..|||           .:..|.:...|.|.:  ||..:..|::|      |
Frog     5 QKL-----ENLASRVFSRG-----------PRGPAPVPPASAGPQAPCLPCNVLSWER------E 47

  Fly   416 LKEKDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQD 480
            :||          .:.:|:|....:.:...|.   ...|...|.:.|||.|.||||.||:  |::
Frog    48 MKE----------FLAKAKEDFLKKWENPAQN---TAHLEQFERIKTLGTGSFGRVMLVR--HKE 97

  Fly   481 RVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIW 545
            ....||:|.|.|:.:|..||.||..:|:.|:.:...||:.||..:|:|...:||::|...|||::
Frog    98 NGSHFAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYSFKDNSNLYMVMEYVAGGEMF 162

  Fly   546 TMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTS 610
            :.||..|.|.:..|:|....::..||||||..:||||||||||::|::||:::.||||||::  .
Frog   163 SHLRRIGRFSEPHARFYASQIVLTFEYLHALDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV--K 225

  Fly   611 SKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMI 675
            .:|||.||||||:||||||:||:::|||:||||:||:|:..|.|||.|..|:|.|..|:.|  .:
Frog   226 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KV 288

  Fly   676 AFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAH 740
            .||.|.|.....|::.|.:...::|.|....|:.|||.||||...||..:..:.:..||:.....
Frog   289 RFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVTDIKGHKWFSTTDWIAVYQKKVEAPFIPKCKG 353

  Fly   741 PTDVRYFDRF 750
            |.|...||.:
Frog   354 PGDTSNFDDY 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	8/32 (25%)
		CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999	17/67 (25%)
		Pkinase	457..717	CDD:278497	118/259 (46%)
		STKc_cGK	463..724	CDD:270724	120/260 (46%)
		S_TK_X	719..>760	CDD:214529	8/31 (26%)
prkaca	XP_012808518.1	STKc_PKA	74..363	CDD:271111	128/294 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910