DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and prkar1aa

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001009989.1	Gene:	prkar1aa / 494533	ZFINID:	ZDB-GENE-050116-2	Length:	379	Species:	Danio rerio

Alignment Length:	360	Identity:	104/360 - (28%)
Similarity:	180/360 - (50%)	Gaps:	22/360 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 QCGEQESRNQNPHLCSSCGMVLPTS-PEFAL-------EALSLGPLSPLASTSSASPSGRTSADE 131
            :|.....::....|...|.:.|.|: ||..:       |.|.|.....:.|...:|....:..||
Zfish    16 ECERYVQKHNIQQLLKDCIVQLCTARPERPMAYLRDYFEKLELEEAKQMVSQQKSSSRSDSREDE 80

  Fly   132 VRPKAMPAA---IKKQGVSAESCVQSMQQSY---SIPIPKYEKDFSDKQQIKDAIMDNDFLKNID 190
            |.|...|..   .::..:|||...:....||   .||     ||:.....:..||..|....::|
Zfish    81 VSPPMNPVVKGRRRRGAISAEVYTEEDATSYVRKVIP-----KDYKTMAALAKAIEKNVLFAHLD 140

  Fly   191 ASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILY 255
            .::..::.|:|:|.:..|||.||::|:.|.:.||...||..|....:.:..:|.|.:|||||::|
Zfish   141 DNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWVTSIGEGGSFGELALIY 205

  Fly   256 NCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVL 320
            ...|.|::|..:. .::|.:||..:::|:|.:.|::.:....||..|.:|.:|.:.....:||.|
Zfish   206 GTPRAATVRAKTN-VKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADAL 269

  Fly   321 ELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKR 385
            |...:..|..|:.||..||.||:|.:|:..|.|:.: .:.|..|:..|:..|||||.||:....|
Zfish   270 ETVQFEDGQKIVVQGQPGDEFFIILEGSAAVLQRRS-ENEEFVEVGRLAPSDYFGEIALLMNRPR 333

  Fly   386 TANIIALSPGVECLTLDRDSFKRLIGDLCELKEKD 420
            .|.::|..| ::|:.|||..|:|::|...::.:::
Zfish   334 AATVVARGP-LKCVKLDRPRFERVLGPCSDILKRN 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	65/202 (32%)
		CAP_ED	185..285	CDD:237999	31/99 (31%)
		CAP_ED	304..419	CDD:237999	39/114 (34%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
prkar1aa	NP_001009989.1	DD_RIalpha_PKA	14..62	CDD:213048	10/45 (22%)
		Crp	129..>255	CDD:223736	39/126 (31%)
		CAP_ED	135..244	CDD:237999	33/109 (30%)
		Crp	247..>357	CDD:223736	41/111 (37%)
		CAP_ED	253..368	CDD:237999	39/117 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810