DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and prkar2ab

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_998123.1	Gene:	prkar2ab / 405894	ZFINID:	ZDB-GENE-040426-2427	Length:	422	Species:	Danio rerio

Alignment Length:	265	Identity:	86/265 - (32%)
Similarity:	147/265 - (55%)	Gaps:	14/265 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 YEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEF 230
            ::|....:|:::||.......|.::..|:.|::|||:...:..||.:|.:|:.|.:.||...|.:
Zfish   142 HQKTDEQRQRLQDACKHILLFKTLEEDQLAEVLDSMFEVLVKPGECIINQGDDGDNFYVIERGVY 206

  Fly   231 -AVMQQGKVLDKMGA---GKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQR 291
             .|:||..:...:|.   ..:|||||::||..|.|:||.|.|.| :|.|||..|.::::....::
Zfish   207 EIVIQQDGLQHSVGRYDHKGSFGELALMYNTPRAATIRALQEGA-LWALDRATFHRLIVKNNAKK 270

  Fly   292 IENSVNFLRSVPLL--MNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRV--- 351
            .....:|:..||||  :.|||.:  ||.|||.:..::.|..||:||.:.|.|:::..|.||:
Zfish   271 RRMYESFIECVPLLKSLQLSERM--KIVDVLGMRSFSDGERIIQQGDSADCFYIVESGEVRIMIR 333

  Fly   352 -TQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCE 415
             ..:......||.|:...|||.||||.||:.:..|.|::.|:. ...||.:|..:|:||:|...:
Zfish   334 SKTRACQLLQEEVEVARCSRGQYFGELALVTKRPRAASVYAVG-DTRCLVIDVQAFERLLGSCKQ 397

  Fly   416 LKEKD 420
            :.:::
Zfish   398 ILKRN 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	72/212 (34%)
		CAP_ED	185..285	CDD:237999	37/103 (36%)
		CAP_ED	304..419	CDD:237999	42/120 (35%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
prkar2ab	NP_998123.1	DD_RII_PKA	5..41	CDD:213046
		Crp	157..>266	CDD:223736	37/109 (34%)
		CAP_ED	161..274	CDD:237999	37/113 (33%)
		Crp	281..>392	CDD:223736	42/113 (37%)
		CAP_ED	283..403	CDD:237999	42/123 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810