DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and CG4839

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster

Alignment Length:	797	Identity:	306/797 - (38%)
Similarity:	442/797 - (55%)	Gaps:	96/797 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 HKLKSVLQQTTNNL-----NVTRNEKAKKKLYSLPE-----QCGEQESRNQNPHLCSSCGMVL-- 96
            |..:...|||.:.|     :...|..||.....:|:     :.|:|::....|...||..:.|
  Fly   231 HTQELSAQQTDDTLSCQSSDANNNSAAKLTNGVVPQEQPEREMGKQQALQAPPRAKSSSNVSLNY 295

  Fly    97 ----------------------PTSPEFALEALSLGPLSPL------------------------ 115
                                  |.:|....|.|.  |.:||
  Fly   296 LAKSQTDSQRRRRVSTMPDINIPPAPPLPPELLV--PGTPLHLRKKRSMERQQQQKQQEQQQQQE 358

  Fly   116 ----ASTSSASPSGRTSADEVRPKAMPAAIKKQG----VSAESCVQSMQQSYSIPIPKYEKDFSD 172
                |:.|....:|...:.:....:.|...:.:|    |.....:||     .|.|....||...
  Fly   359 IQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQS-----DIEIESIAKDEGT 418

  Fly   173 KQQIKDAIMDNDFLKNIDASQVRELV-DSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQG 236
            :..|:.||..||||.|:...:.:|:| ::|...|......:|||.|.|:.:||||.|::.|::.|
  Fly   419 RNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQYDVIRGG 483

  Fly   237 KVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRS 301
            :::...|....|||||||||..|.|||...:: ||||.:.|..|:.||..:|.:..|.::.||||
  Fly   484 QLVASFGPATVFGELAILYNAPRQASIEAATD-ARVWKIARETFRAIMQISGSREREENLQFLRS 547

  Fly   302 VPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELR 366
            .|.|....:.||.|:.|:|:.:||...:.|:|:|..|:.|::|..|.|.: :||.....|:. :.
  Fly   548 APFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTVTI-KKLDEQQQEQI-VA 610

  Fly   367 TLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMK 431
            ...||||||||||:|.|.|.|::.|.:||.|.|.|||::|...:|.:.:|:||.        :.:
  Fly   611 NRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLGTIKQLREKP--------SSQ 667

  Fly   432 QAQESCRDEPKE-QLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHI 495
            :...|.|...|. :...|:..:.:::|:.::|||.|.||||:|| |::|..:   |||.:||..:
  Fly   668 RNDTSGRSSTKSLEFDNEYSQVAISELKKIATLGCGAFGRVDLV-AYNQQAL---ALKIIKKIEV 728

  Fly   496 VDTKQEEHIFSERHIMLSSR-SPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAA 559
            |...|.||:::|:::|:..| ||||.:||||:|::||||.|:||||||::||::..|..|::..|
  Fly   729 VKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTA 793

  Fly   560 QFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVA 624
            :||.|||::||:|||:...||||||||||||...||.|:|||||||.:..:.||.||.|||||||
  Fly   794 KFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQNEKTNTFAGTPEYVA 858

  Fly   625 PEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLI 689
            |||||::||||||||||||||::|||.|..||...:.::.|..||.|||:|..|..|.:.|..|:
  Fly   859 PEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLV 923

  Fly   690 KRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDL 754
            :.||:.:|:||||||..||.|||:|.||...||..|..:.|..|..||:...||::||.  |..:
  Fly   924 RHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPLKSWTDLQYFG--PSGV 986

  Fly   755 N---EPPDELSGWDADF 768
            .   |||:||||||.||
  Fly   987 ENDYEPPEELSGWDKDF 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	81/203 (40%)
		CAP_ED	185..285	CDD:237999	40/100 (40%)
		CAP_ED	304..419	CDD:237999	44/114 (39%)
		Pkinase	457..717	CDD:278497	144/260 (55%)
		STKc_cGK	463..724	CDD:270724	146/261 (56%)
		S_TK_X	719..>760	CDD:214529	15/43 (35%)
CG4839	NP_609349.1	Crp	428..577	CDD:223736	58/149 (39%)
		CAP_ED	431..539	CDD:237999	42/108 (39%)
		Crp	544..>650	CDD:223736	46/107 (43%)
		CAP_ED	550..663	CDD:237999	44/114 (39%)
		S_TKc	695..951	CDD:214567	143/259 (55%)
		STKc_cGK	700..957	CDD:270724	145/260 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I744
eggNOG	1	0.900	-	-		E1_COG0664
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I1043
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1102
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	1	1.100	-	-	P	PTHR24353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
	9	8.870