DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and sws

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_511075.3	Gene:	sws / 31716	FlyBaseID:	FBgn0003656	Length:	1425	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	90/485 - (18%)
Similarity:	166/485 - (34%)	Gaps:	148/485 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VQALREMVRSRESELVKLHREIH-KLKSVLQQTTNN---LN--VTRNEKAKKKLYSLPEQCGEQE 80
            :||..|:.:.....::::.:.|. :|:.||.....|   ||  :.:|....|.:.::......|.
  Fly   277 MQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRYKSVSTMSGPINSQT 341

  Fly    81 SRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAMPAAIKKQG 145
            |::...         .|..|...:..::|     :.|..|.:.|...|....||.:.|:...::
  Fly   342 SQSSRQ---------APNGPPMVISQMNL-----MQSAVSGTGSSGVSVTVTRPPSSPSRHSRE- 391

  Fly   146 VSAESCVQSMQQSYSIPIPKYE-------------------KDFSDKQQIKDAI----------- 180
                      :.:.|.|.|..:                   .|...:||.:.::
  Fly   392 ----------EHTLSDPNPNPDGSFHGTTNLFTEVHGDAPNADLFHQQQQQHSVGNLSTRRSSIT 446

  Fly   181 -MDND----------FLKNIDASQVR-ELVDSMYSKSIAAGE--------FV-IREGEVGAHLYV 224
             |..|          ...:||...|: ..|||: .|.:...|        || :||.|....|..
  Fly   447 LMAPDGSHSCLQTPGVTTSIDMRLVQSSAVDSL-RKELGLSEEDSHIIEPFVELRELEPNVTLIT 510

  Fly   225 SA-----------AGEFAVMQQGK------------VLDKMGAGKAFGELAILYNCTRTASIRVL 266
            ..           .|..||.|..:            ::..:..|:..|.||:|.......:||..
  Fly   511 EGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEIVGGLAMLTGEASAYTIRSR 575

  Fly   267 SEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVP-LLMNLSEELLAKIADV-------LELE 323
            | ..|:..:.|....|||               |..| ::::|...::.:::.:       |:..
  Fly   576 S-ITRIAFIRRAAIYQIM---------------RQRPRIVLDLGNGVVRRLSPLVRQCDYALDWI 624

  Fly   324 FYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTAN 388
            |..:|..:.||..:.||.:::..|.:|  ..:|....::..:....:||..|...:|.|..||..
  Fly   625 FLESGRAVYRQDESSDSTYIVLSGRMR--SVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTT 687

  Fly   389 IIALSPGVECLTLDRDSFKRLIGDLCELKE 418
            ::|:          |||      :|.:|.|
  Fly   688 VMAV----------RDS------ELAKLPE 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	50/253 (20%)
		CAP_ED	185..285	CDD:237999	30/132 (23%)
		CAP_ED	304..419	CDD:237999	25/122 (20%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
sws	NP_511075.3	Crp	168..>310	CDD:223736	7/32 (22%)
		CAP_ED	174..295	CDD:237999	3/17 (18%)
		Crp	483..>611	CDD:223736	27/143 (19%)
		CAP_ED	484..602	CDD:237999	26/133 (20%)
		CAP_ED	620..719	CDD:237999	24/100 (24%)
		Crp	624..>727	CDD:223736	23/96 (24%)
		Pat_PNPLA6_PNPLA7	935..1240	CDD:132864
		RssA	940..1222	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900