DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and Prkar2a

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_062137.1	Gene:	Prkar2a / 29699	RGDID:	3393	Length:	401	Species:	Rattus norvegicus

Alignment Length:	368	Identity:	100/368 - (27%)
Similarity:	173/368 - (47%)	Gaps:	44/368 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PTSPEFALEALS-LGPLSPLASTSSASPSGRTSADEVRPKAMPAAIKKQGVSAESCVQSMQQSYS 160
            |...:||:|..: |.......|.|..:|.....|.|  ...:| .|::.|   ||...|..:...
  Rat    27 PDLVDFAVEYFTRLREARRQESDSFIAPPTTFHAQE--SSGVP-VIEEDG---ESESDSDDEDLE 85

  Fly   161 IPIPK--------------------------YEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVD 199
            :|||.                          :.|....:.::::|..|....||:|..|:.:::|
  Rat    86 VPIPSKFTRRVSVCAETFNPDEEEDNDPRVVHPKTDEQRYRLQEACKDILLFKNLDQEQLSQVLD 150

  Fly   200 SMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVM----QQGKVLDKMGAGKAFGELAILYNCTRT 260
            :|:.|.:...|.||.:|:.|.:.||...|.:.::    .|.:.:.:.....:|||||::||..|.
  Rat   151 AMFEKIVKTDEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRA 215

  Fly   261 ASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFY 325
            |:|...|:.: :|.|||..|::|::....::.:...:|:.||||..:|......||.||:..:.|
  Rat   216 ATIVATSDGS-LWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLFKSLEMSERMKIVDVIGEKIY 279

  Fly   326 AAGTYIIRQGTAGDSFFLISQGNVRV-TQKLTPTSP----EETELRTLSRGDYFGEQALINEDKR 385
            ..|..||.||...|||::|..|.|.: .:..|.|:.    :|.|:....:|.||||.||:....|
  Rat   280 KDGERIITQGEKADSFYIIESGEVSILIRSKTKTNKNGGNQEVEIAHCHKGQYFGELALVTNKPR 344

  Fly   386 TANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKL 428
            .|:..|:. .|:||.:|..:|:||:|...::.:::......:|
  Rat   345 AASAYAVG-DVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQL 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	66/211 (31%)
		CAP_ED	185..285	CDD:237999	33/103 (32%)
		CAP_ED	304..419	CDD:237999	40/119 (34%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
Prkar2a	NP_062137.1	Dimerization and phosphorylation	2..135		22/113 (19%)
		DD_RIIalpha_PKA	4..44	CDD:213050	5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..85		8/35 (23%)
		Crp	132..>241	CDD:223736	34/109 (31%)
		CAP_ED	136..248	CDD:237999	33/112 (29%)
		Crp	252..>368	CDD:223736	42/116 (36%)
		CAP_ED	258..379	CDD:237999	40/121 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810