DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and Prkacb

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_006233513.1	Gene:	Prkacb / 293508	RGDID:	1310574	Length:	398	Species:	Rattus norvegicus

Alignment Length:	346	Identity:	136/346 - (39%)
Similarity:	204/346 - (58%)	Gaps:	25/346 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 ESRKLAMK----QAQE--SCRDEPKEQL----QQEF---------PDLKLTDLEVVSTLGIGGFG 469
            :.:|.|::    ||.|  :..|:|.::.    :::|         .:..|.|.|...|||.|.||
  Rat    39 QDQKAALEEEGLQASEHTASWDKPMKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFG 103

  Fly   470 RVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYM 534
            ||.|||  |:.....:|:|.|.|:.:|..||.||..:|:.|:.:...||:.||..:|:|...:||
  Rat   104 RVMLVK--HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYM 166

  Fly   535 LLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIV 599
            ::|...|||:::.||..|.|.:..|:|....::..|||||:..:||||||||||::|.:||:::.
  Rat   167 VMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVT 231

  Fly   600 DFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQT 664
            ||||||::  ..:|||.||||||:||||||:||:::|||:||||:||:|:..|.|||.|..|:|.
  Rat   232 DFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQI 294

  Fly   665 YNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQL 729
            |..|:.|  .:.||.|.|.....|::.|.:...::|.|....|:.|||.||||...||..:..:.
  Rat   295 YEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRK 357

  Fly   730 LIPPFVRPIAHPTDVRYFDRF 750
            :..||:.......|...||.:
  Rat   358 VEAPFIPKFRGSGDTSNFDDY 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736
		CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		Pkinase	457..717	CDD:278497	117/259 (45%)
		STKc_cGK	463..724	CDD:270724	119/260 (46%)
		S_TK_X	719..>760	CDD:214529	7/32 (22%)
Prkacb	XP_006233513.1	PTZ00263	79..398	CDD:140289	128/306 (42%)
Prkacb	XP_006233513.1	STKc_PKA	89..378	CDD:271111	127/294 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840