Protein Alignment Pkg21D and RPS6KA6

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: XP_016884912.1
• Gene: RPS6KA6 / 27330
• HGNCID: 10435
• Length: 762
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 119/332 - (35%)
• Similarity: 185/332 - (55%)
• Gaps: 32/332 - (9%)

  Fly   435 ESCRDE-----------PKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELV-KAHHQDRVDIFAL 487
            :||.||           .||..::..|    ...|::..||.|.||:|.|| |....|...::|:
Human    61 DSCHDEGVVKEIPITHHVKEGYEKADP----AQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAM 121

  Fly   488 KCLKK-----RHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTM 547
            |.|||     |..|.||.      ||.|::....|||.:|:..|:.|..:|::|:...||:::|.
Human   122 KVLKKASLKVRDRVRTKM------ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTR 180

  Fly   548 LRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQ-IGTSS 611
            |.....|.:...:|.:..:..|.::||..||:||||||||::|||.|::|:.|||.:|: :....
Human   181 LSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEK 245

  Fly   612 KTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIA 676
            |.::||||.||:|||::..:||.::.|:|:.|:|:.|:|.||.||...|..:|.|:|||.  .:.
Human   246 KAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKA--KLG 308

  Fly   677 FPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHP 741
            .|:.:|..|..|::.|.:..|:.|||.:  |:::||:|.:|...|||.|..:.:.|||......|
Human   309 MPQFLSAEAQSLLRMLFKRNPANRLGSE--GVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKP 371

  Fly   742 TDVRYFD 748
            .|...||
Human   372 DDTFCFD 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		STKc_cGK	463..724	CDD:270724	102/267 (38%)
		S_TK_X	719..>760	CDD:214529	11/30 (37%)
RPS6KA6	XP_016884912.1	STKc_RSK_N	94..408	CDD:270734	111/295 (38%)
		STKc_RSK4_C	438..732	CDD:271079