DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and Prkar1a

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_037313.1	Gene:	Prkar1a / 25725	RGDID:	3391	Length:	381	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	113/430 - (26%)
Similarity:	197/430 - (45%)	Gaps:	71/430 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAGMLTDREREAIVSNLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNVTRNEKA 65
            ||:|.:...|.|          ::|||         .:|:.:.|.::::|:.:...|...|.|:.
  Rat     1 MASGSMAASEEE----------RSLRE---------CELYVQKHNIQALLKDSIVQLCTARPERP 46

  Fly    66 KKKLYSLPEQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSG-RTSA 129
            ...|....|:..::|:|                                  ...|...|| ||.:
  Rat    47 MAFLREYFERLEKEEAR----------------------------------QIQSLQKSGIRTDS 77

  Fly   130 --DEVRPKAMPAAIK----KQGVSAESCVQSMQQSY---SIPIPKYEKDFSDKQQIKDAIMDNDF 185
              ||:.|......:|    :..:|||...:....||   .||     ||:.....:..||..|..
  Rat    78 REDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIP-----KDYKTMAALAKAIEKNVL 137

  Fly   186 LKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGE 250
            ..::|.::..::.|:|:..|..|||.||::|:.|.:.||...||..|....:....:|.|.:|||
  Rat   138 FSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGE 202

  Fly   251 LAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAK 315
            ||::|...|.|:::..:. .::|.:||..:::|:|.:.|::.:....||..|.:|.:|.:.....
  Rat   203 LALIYGTPRAATVKAKTN-VKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLT 266

  Fly   316 IADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALI 380
            :||.||...:..|..|:.||..||.||:|.:|...|.|:.: .:.|..|:..|...|||||.||:
  Rat   267 VADALEPVQFEDGQKIVVQGEPGDEFFIILEGTAAVLQRRS-ENEEFVEVGRLGPSDYFGEIALL 330

  Fly   381 NEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKD 420
            ....|.|.::|..| ::|:.|||..|:|::|...::.:::
  Rat   331 MNRPRAATVVARGP-LKCVKLDRPRFERVLGPCSDILKRN 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	64/202 (32%)
		CAP_ED	185..285	CDD:237999	30/99 (30%)
		CAP_ED	304..419	CDD:237999	39/114 (34%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
Prkar1a	NP_037313.1	Dimerization and phosphorylation	2..136		37/191 (19%)
		DD_RIalpha_PKA	14..63	CDD:213048	12/57 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..96		9/30 (30%)
		Pseudophosphorylation motif	96..100		0/3 (0%)
		CAP_ED	137..246	CDD:237999	32/109 (29%)
		CAP_ED	255..370	CDD:237999	39/117 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810