Protein Alignment Pkg21D and SGK3

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_037389.4
• Gene: SGK3 / 23678
• HGNCID: 10812
• Length: 496
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 132/450 - (29%)
• Similarity: 219/450 - (48%)
• Gaps: 76/450 - (16%)

  Fly   357 PTSPEETE----------LRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIG 411
            |:|.|..|          |.::.|.::|..:.....||....:....|.:..    :...||:.|
Human    19 PSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMAL----KIPAKRIFG 79

  Fly   412 DLCE---LKEKDYG------------------DESRKLAM---KQAQESCRDEPKEQLQQEF--- 449
            |..:   :|::..|                  |....|.|   |...:...||.:...|:..
Human    80 DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTS 144

  Fly   450 ----------PDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVD--IFALKCLKKRHIVDTKQEE 502
                      |..|.||.:.:..:|.|.||:|.|.|.    ::|  .:|:|.|:|:.:::.|:::
Human   145 QNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKR----KLDGKFYAVKVLQKKIVLNRKEQK 205

  Fly   503 HIFSERHIMLSS-RSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCV 566
            ||.:||:::|.: :.||:..|:.:|:..:.:|.:|:...|||::..|:...||.::.|:|....:
Human   206 HIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEI 270

  Fly   567 LQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQ-IGTSSKTWTFCGTPEYVAPEIILN 630
            ..|..|||:..|:||||||||::||..|:|.:.|||..|: |..|..|.||||||||:|||:|..
Human   271 ASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRK 335

  Fly   631 KGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLIL-------KGIDMIAFPKHISRWAVQL 688
            :.:|..||:|.||.:::|:|.|.|||...|..:.|:.||       .|:.:.|       |::
Human   336 QPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTA-------WSI-- 391

  Fly   689 IKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFD 748
            ::.|.......|||.:...: :|:.|.:|....|..|..:.:.|||...:|.|.|:|.||
Human   392 LEELLEKDRQNRLGAKEDFL-EIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFD 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999	15/74 (20%)
		STKc_cGK	463..724	CDD:270724	95/271 (35%)
		S_TK_X	719..>760	CDD:214529	10/29 (34%)
SGK3	NP_037389.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		1/1 (100%)
		PX_CISK	12..120	CDD:132780	18/104 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..156		4/34 (12%)
		STKc_SGK3	165..490	CDD:270755	104/299 (35%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		2/9 (22%)