Protein Alignment Pkg21D and AKT2

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 131/453 - (28%)
• Similarity: 225/453 - (49%)
• Gaps: 34/453 - (7%)

  Fly   315 KIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEET--ELRTLSRGDYFGEQ 377
            :::.:.|...:..|.||   .|....:||:......:..|..|.:|::|  .|...|    ..|.
Human     3 EVSVIKEGWLHKRGEYI---KTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFS----VAEC 60

  Fly   378 ALINEDKRTANIIALSPGVECLTL--------------DRDSFKRLIGDLC-ELKEKDYGDESRK 427
            .|:..::...|...    :.||..              :|:.:.|.|..:. .||::..|::...
Human    61 QLMKTERPRPNTFV----IRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMD 121

  Fly   428 LAMKQAQESCRDEPKE-QLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLK 491
            .......:|...|..| .:.:....:.:.|.:.:..||.|.||:|.||:.....|  .:|:|.|:
Human   122 YKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGR--YYAMKILR 184

  Fly   492 KRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFED 556
            |..|:...:..|..:|..::.::|.||:..|...|:....:..::|...|||::..|.....|.:
Human   185 KEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE 249

  Fly   557 NAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQ-IGTSSKTWTFCGTP 620
            ..|:|....::.|.||||:|.::|||:|.||||||:.|::||.|||..|: |...:...||||||
Human   250 ERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP 314

  Fly   621 EYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWA 685
            ||:|||::.:..:.||||:|.||::::|::.|..||...|..:.:.|||  ::.|.||:.:|..|
Human   315 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL--MEEIRFPRTLSPEA 377

  Fly   686 VQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFD 748
            ..|:..|.:..|.:|||......:::.:|::||..:|..:..:.|:|||...:....|.||||
Human   378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999	23/120 (19%)
		STKc_cGK	463..724	CDD:270724	94/261 (36%)
		S_TK_X	719..>760	CDD:214529	10/30 (33%)
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947	21/117 (18%)
		STKc_PKB_beta	156..478	CDD:173686	103/289 (36%)