DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and Prkx

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_058675.1	Gene:	Prkx / 19108	MGIID:	1309999	Length:	355	Species:	Mus musculus

Alignment Length:	349	Identity:	136/349 - (38%)
Similarity:	208/349 - (59%)	Gaps:	13/349 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   411 GDLCELKEKDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVK 475
            |....:|:.|:.....|::...|      :||.:...:.....|.|.:.::|:|.|.||||.|||
Mouse     6 GAAATVKDPDHDPVKTKVSAPAA------DPKPRTSSQKAGHSLQDWDTIATVGTGTFGRVNLVK 64

  Fly   476 AHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACM 540
              .:......|||.:....::..|||:|:.:|:.::.....||:.:|..|..|.:::|||:|...
Mouse    65 --EKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVP 127

  Fly   541 GGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAK 605
            |||::|.||:||.|...|:.|....::.|.||||::.|:||||||||::||..|::|:.||||||
Mouse   128 GGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAK 192

  Fly   606 QIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILK 670
            ::  ..:|||.||||||:|||:|.:|||.||||:|||||||.|:|:|.|||...:|...|..||
Mouse   193 KL--VDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKIL- 254

  Fly   671 GIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFV 735
             ...|.||:.:...:..|||:|.....:.|||....|.:|||:|:||.|.:|:.:..:.|.||.|
Mouse   255 -ACKIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIV 318

  Fly   736 RPIAHPTDVRYFDRFP-CDLNEPP 758
            ..::...|:..|:.:| .:|::.|
Mouse   319 PKLSGDGDISNFETYPESELDKTP 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736
		CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999	2/7 (29%)
		Pkinase	457..717	CDD:278497	114/259 (44%)
		STKc_cGK	463..724	CDD:270724	117/260 (45%)
		S_TK_X	719..>760	CDD:214529	11/41 (27%)
Prkx	NP_058675.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		7/41 (17%)
		PTZ00263	31..355	CDD:140289	130/318 (41%)
		STKc_PRKX_like	44..335	CDD:270763	125/296 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..355		7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910