DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and Prkar2b

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001351336.1	Gene:	Prkar2b / 19088	MGIID:	97760	Length:	416	Species:	Mus musculus

Alignment Length:	376	Identity:	104/376 - (27%)
Similarity:	177/376 - (47%)	Gaps:	52/376 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 EFALEALS-LGPLSPLASTSSASPSGRTSADEVRPKAMPAAIKKQGVS-AESCVQSMQQ------ 157
            ||||:..: |...:.....:.....|||..|  ...|....|..:||: ||..::|..:
Mouse    30 EFALQHFTRLQQENERKGAARFGHEGRTWGD--AGAAAGGGIPSKGVNFAEEPMRSDSENGEEEE 92

  Fly   158 -----SYSIPI----------------PKYEKDFSD-----------KQQIKDAIMDNDFLKNID 190
                 :::.|:                |..|:|.::           :.::::|..|....||:|
Mouse    93 AAEAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLD 157

  Fly   191 ASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQ----GKVLDKMGAGKAFGEL 251
            ..|:.:::|:|:.|.:..||.||.:|:.|.:.||...|.|.:..:    |:.:.......:||||
Mouse   158 PEQMSQVLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGEL 222

  Fly   252 AILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKI 316
            |::||..|.|:|...|..| :|.|||..|::|::....::.:...:|:.|:|.|.:|......|:
Mouse   223 ALMYNTPRAATITATSPGA-LWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKV 286

  Fly   317 ADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEE----TELRTLSRGDYFGEQ 377
            .||:..:.|..|..||.||...||||::..|.|::|.|....|..|    .|:....||.||||.
Mouse   287 VDVIGTKVYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGEL 351

  Fly   378 ALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKL 428
            ||:....|.|:..|:.. |:||.:|..:|:||:|...|:.:::......:|
Mouse   352 ALVTNKPRAASAHAIGT-VKCLAMDVQAFERLLGPCMEIMKRNIATYEEQL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	69/210 (33%)
		CAP_ED	185..285	CDD:237999	36/103 (35%)
		CAP_ED	304..419	CDD:237999	42/118 (36%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
Prkar2b	NP_001351336.1	Dimerization and phosphorylation	1..151		22/122 (18%)
		DD_RIIbeta_PKA	3..43	CDD:213051	5/12 (42%)
		CAP_ED	152..265	CDD:237999	36/113 (32%)
		CAP_ED	274..394	CDD:237999	42/120 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810