DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and Prkar1b

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001240819.1	Gene:	Prkar1b / 19085	MGIID:	97759	Length:	381	Species:	Mus musculus

Alignment Length:	391	Identity:	103/391 - (26%)
Similarity:	192/391 - (49%)	Gaps:	48/391 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLPEQCGEQE-----SRNQNPHLCSSCGMVLP 97
            :::.:.|.::.||::...:|.|.:.::..:.|....|:..::|     :|.::...|.|..
Mouse    19 EMYVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHFEKLEKEENRQILARQKSNSQCDSHD---- 79

  Fly    98 TSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAMPAAIKKQGVSAESCVQSMQQSY--- 159
                   |.:|..|.:|:                     :.|..::.|||||...:....||
Mouse    80 -------EEISPTPPNPV---------------------VKARRRRGGVSAEVYTEEDAVSYVRK 116

  Fly   160 SIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYV 224
            .||     ||:.....:..||..|....::|.::..::.|:|:..:...||.||::|..|.:.||
Mouse   117 VIP-----KDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIGGETVIQQGNEGDNFYV 176

  Fly   225 SAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGL 289
            ...||..|...|:.:..:..|.:|||||::|...|.|:::..:: .::|.:||..:::|:|.:.|
Mouse   177 IDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTD-LKLWGIDRDSYRRILMGSTL 240

  Fly   290 QRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQK 354
            ::.:....||..|.:|.:|.:.....:||.||...:..|..|:.||..||.|::|::|...|.|:
Mouse   241 RKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQR 305

  Fly   355 LTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEK 419
            .:| :.|..|:..|...|||||.||:....|.|.::|..| ::|:.|||..|:|::|...|:.::
Mouse   306 RSP-NEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGP-LKCVKLDRPRFERVLGPCSEILKR 368

  Fly   420 D 420
            :
Mouse   369 N 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	62/202 (31%)
		CAP_ED	185..285	CDD:237999	28/99 (28%)
		CAP_ED	304..419	CDD:237999	40/114 (35%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
Prkar1b	NP_001240819.1	Dimerization and phosphorylation	1..136		29/153 (19%)
		DD_RIbeta_PKA	11..64	CDD:213049	8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..88		6/32 (19%)
		Pseudophosphorylation motif	96..100		0/3 (0%)
		CAP_ED	137..246	CDD:237999	30/109 (28%)
		CAP_ED	255..370	CDD:237999	40/117 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810