Protein Alignment Pkg21D and Prkcd

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_001297611.1
• Gene: Prkcd / 18753
• MGIID: 97598
• Length: 700
• Species: Mus musculus
• Alignment Length: 675
• Identity: 167/675 - (24%)
• Similarity: 282/675 - (41%)
• Gaps: 162/675 - (24%)

  Fly   131 EVRPKAMPAAIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVR 195
            :::|:|......:..:....|.|||:.......|...:    :..||.|.:  .::||      .
Mouse   107 DLQPQAKVLMCVQYFLEDGDCKQSMRSEEEAKFPTMNR----RGAIKQAKI--HYIKN------H 159

  Fly   196 ELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEF--AVMQQG------------KVLDKMGAGK 246
            |.:.:.:                |...:.|...||  .:.:||            |.:||
Mouse   160 EFIATFF----------------GQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDK----- 203

  Fly   247 AFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIM--------------------MCTGLQR 291
                  |:..||.||:      .:|..:..:..|...|                    :..||.:
Mouse   204 ------IIGRCTGTAT------NSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVK 256

  Fly   292 IENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLT 356
                 ..|:.....||:..:...|:|::..          |.|....::...::|   |.::||.
Mouse   257 -----QGLKCEDCGMNVHHKCREKVANLCG----------INQKLLAEALNQVTQ---RSSRKLD 303

  Fly   357 PT-----------SPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLI 410
            .|           .||      :|..|..||         ..:.|:|.........::||
Mouse   304 TTESVGIYQGFEKKPE------VSGSDILGE---------AGSHISLKLSFPSRAKEKDS----- 348

  Fly   411 GDLCELKEKDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVK 475
            .:.|: ....||        |..:.|.|             ..|.:......||.|.||:|.|.:
Mouse   349 SETCD-NNGTYG--------KIWEGSTR-------------CTLENFTFQKVLGKGSFGKVLLAE 391

  Fly   476 AHHQDRVDIFALKCLKKRHI-VDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEAC 539
            ...:|:  .||:|||||..: :|...|..:..:|.:.|:..|||:..|..||:.:.:::.::|..
Mouse   392 LKGKDK--YFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFL 454

  Fly   540 MGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFA 604
            .||::...::|:|.||...|.|....::...::||::||||||||.:|:|||..|::||.|||..
Mouse   455 NGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMC 519

  Fly   605 KQ-IGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLI 668
            |: |....:..||||||:|:||||:....:..:||:|:.|:|::|:|.|..||...|..:.:..|
Mouse   520 KENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESI 584

  Fly   669 LKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPP 733
              .:|...:|:.|::.:..::::|....|.:|||. ||   :|:.|.:|...:|..|..:.:.||
Mouse   585 --RVDTPHYPRWITKESKDIMEKLFERDPDKRLGV-TG---NIRIHPFFKTINWSLLEKRKVEPP 643

  Fly   734 FVRPIAHPTDVRYFDRFPCDLNEPP 758
            |...:..|:|...||  |..|||.|
Mouse   644 FKPKVKSPSDYSNFD--PEFLNEKP 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999	20/133 (15%)
		CAP_ED	304..419	CDD:237999	22/125 (18%)
		STKc_cGK	463..724	CDD:270724	93/262 (35%)
		S_TK_X	719..>760	CDD:214529	14/40 (35%)
Prkcd	NP_001297611.1	C1_nPKC_theta-like_rpt1	152..212	CDD:410384	15/94 (16%)
		C1_nPKC_theta-like_rpt2	231..280	CDD:410387	7/53 (13%)
		Protein Kinases, catalytic domain	377..692	CDD:473864	106/300 (35%)