Protein Alignment Pkg21D and Prkcb

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_032881.1
• Gene: Prkcb / 18751
• MGIID: 97596
• Length: 673
• Species: Mus musculus
• Alignment Length: 787
• Identity: 183/787 - (23%)
• Similarity: 310/787 - (39%)
• Gaps: 214/787 - (27%)

  Fly    33 ESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLPEQC----------GEQESRNQNPH 87
            |...|:..|     |..|:|  .|::..:|.|...:.:..|..|          |:|..:.|
Mouse    14 EESTVRFAR-----KGALRQ--KNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQ--- 68

  Fly    88 LCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSAD-EVRPKAMPA----------AI 141
            :|  |.:|.....||...:      .|.|....||...|:... ::...:.|.          .:
Mouse    69 VC--CFVVHKRCHEFVTFS------CPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGL 125

  Fly   142 KKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSI 206
            ..||:..::|:.::.:...:.:|                                        |:
Mouse   126 IHQGMKCDTCMMNVHKRCVMNVP----------------------------------------SL 150

  Fly   207 AAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVL---DKMGAGKAFGELAIL-----YNCTRTASI 263
            ...:...|.|.:....::.......|::..|.|   |..|....:.:|.::     .:..:|.:|
Mouse   151 CGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTI 215

  Fly   264 RV-------------LSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAK 315
            :.             |.|:.:    |||:..:|....    :.:..:|:.|  |...:||...|.
Mouse   216 KCSLNPEWNETFRFQLKESDK----DRRLSVEIWDWD----LTSRNDFMGS--LSFGISELQKAG 270

  Fly   316 IADVLELEFYAAGTY----IIRQGTAGDSFFLISQGNVRVTQKLT-------PTSPEETELRTLS 369
            :....:|.....|.|    :..:|         |:||..:.||..       ..:|||....|:|
Mouse   271 VDGWFKLLSQEEGEYFNVPVPPEG---------SEGNEELRQKFERAKIGQGTKAPEEKTANTIS 326

  Fly   370 RGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQ 434
            :.|..|     |.|:
Mouse   327 KFDNNG-----NRDR-------------------------------------------------- 336

  Fly   435 ESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTK 499
                             :||||...:..||.|.||:|.|.:....|  :::|:|.|||..::...
Mouse   337 -----------------MKLTDFNFLMVLGKGSFGKVMLSERKGTD--ELYAVKILKKDVVIQDD 382

  Fly   500 QEEHIFSERHIM-LSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFII 563
            ..|....|:.:: |..:.||:.:|:..|:....:|.::|...||::...::..|.|::..|.|..
Mouse   383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447

  Fly   564 GCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQ-IGTSSKTWTFCGTPEYVAPEI 627
            ..:.....:|.::||||||||.:|:|||..|::||.|||..|: |.....|.||||||:|:||||
Mouse   448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512

  Fly   628 ILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRL 692
            |..:.:.::||:||.|:|::|:|.|..||...|..:.:..|::  ..:|:||.:|:.||.:.|.|
Mouse   513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME--HNVAYPKSMSKEAVAICKGL 575

  Fly   693 CRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRF----PCD 753
            ....|.:|||....|.:|||:|.:|...||:.|..:.:.||: :|.|...:...||||    |..
Mouse   576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPY-KPKACGRNAENFDRFFTRHPPV 639

  Fly   754 LNEPPDE 760
            |. |||:
Mouse   640 LT-PPDQ 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999	17/120 (14%)
		CAP_ED	304..419	CDD:237999	22/125 (18%)
		STKc_cGK	463..724	CDD:270724	95/262 (36%)
		S_TK_X	719..>760	CDD:214529	15/44 (34%)
Prkcb	NP_032881.1	C1_cPKC_rpt1	35..92	CDD:410383	14/67 (21%)
		C1_cPKC_rpt2	102..155	CDD:410386	6/92 (7%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	24/139 (17%)
		STKc_cPKC_beta	341..663	CDD:270767	110/311 (35%)