Protein Alignment Pkg21D and pkg-2

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_741467.1
• Gene: pkg-2 / 177659
• WormBaseID: WBGene00015650
• Length: 617
• Species: Caenorhabditis elegans
• Alignment Length: 677
• Identity: 252/677 - (37%)
• Similarity: 387/677 - (57%)
• Gaps: 70/677 - (10%)

  Fly   101 EFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAMPAAIKKQGVSAESCVQSMQQSYSIPIPK 165
            :|..|||    |:.|..........|...||.|   |....:|..:|:|..:|       :..|.
 Worm     2 DFTREAL----LAELELKDDIIEQLRKELDEYR---MMNTTRKTAISSEPDIQ-------VKRPI 52

  Fly   166 YEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEF 230
            ..|..:..:.|.:|:..|.||:|:||:|:.::..:||...:.||..:||:|::|:.:||...|:.
 Worm    53 IGKSDAAFETIGNALRLNSFLRNLDATQIEKISSAMYPVEVPAGAIIIRQGDLGSIMYVIQEGKV 117

  Fly   231 AVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENS 295
            .|::..:.:..|..|..|||||||::|.|||::|.: |:..:|.::|.||..|||.:..::..:.
 Worm   118 QVVKDNRFVRTMEDGALFGELAILHHCERTATVRAI-ESCHLWAIERNVFHAIMMESAREKTMSF 181

  Fly   296 VNFLRSVPLLMNLSEELLAKIAD-VLELEFYAAGTYIIRQGTAGDSFFLISQGNVRV-----TQK 354
            ...|:.........||:|.:||: ..|:.:.|....:::.    ...:|:.:|:|..     ..|
 Worm   182 KRHLKYSARFGGYPEEVLLRIAEFCTEMRYDAREELVVKP----QYVYLVCRGSVLCDDQGEVSK 242

  Fly   355 LTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCE-LKE 418
            :  .:.::.|||...:|.:  |:..:.|.  .|::|                |..:..||: |..
 Worm   243 I--VAGQDFELRCGRKGRF--ERFFVLEG--PAHLI----------------KMHVEQLCKALDT 285

  Fly   419 KDYGDESRKLAMKQAQESCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVD 483
            .|..||.|..|....:|:              |::|.||:.|||||:|||||||||::...   .
 Worm   286 TDLDDEIRPRASSTIEEA--------------DVELEDLQRVSTLGMGGFGRVELVRSASS---R 333

  Fly   484 IFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTML 548
            .:|||.:.|.|||:||||.|:.|||.|::...:.:|.|:|:|:||.:.:|||:|.|:||||||:|
 Worm   334 TYALKIMNKAHIVETKQESHVVSERRILMQCDNDYIVRMYKTYRDSEKIYMLMEPCLGGEIWTIL 398

  Fly   549 RDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKT 613
            |.:|.|:::..:|.....::|.||||.:.|:||||||||::||..|:.|:|||||||::....:|
 Worm   399 RKKGRFDNDLTRFYCAGAMEALEYLHRKNIVYRDLKPENMLLDRNGWPKLVDFGFAKKLKNGGRT 463

  Fly   614 WTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFP 678
            ||||||.|||||||:||||||.:||.|||||.:.|||.|:||||:.|||.|||.||||::..|:|
 Worm   464 WTFCGTAEYVAPEIVLNKGHDLSVDIWALGIFMCELLTGSPPFSSTDPMVTYNAILKGLEKWAWP 528

  Fly   679 KHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTD 743
            :.:::.|:.::..||:..|:||||:  |.|.:|:.|.||..||:.|..:..:.|||:..:|:..|
 Worm   529 RFVTKEAIDMMLSLCKYEPTERLGF--GDIGEIRHHIWFDNFDFVGFRAHRIRPPFIPSVANDID 591

  Fly   744 VRYFDRFPC--DLNEPPDELSGWDADF 768
            ...||.||.  :.....|| ||||.||
 Worm   592 TSNFDTFPAFDNFASGSDE-SGWDIDF 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999	38/99 (38%)
		CAP_ED	304..419	CDD:237999	23/121 (19%)
		STKc_cGK	463..724	CDD:270724	137/260 (53%)
		S_TK_X	719..>760	CDD:214529	12/42 (29%)
pkg-2	NP_741467.1	CAP_ED	72..173	CDD:237999	40/101 (40%)
		STKc_cGK	316..572	CDD:270724	137/260 (53%)
		S_TK_X	566..617	CDD:214529	18/51 (35%)