DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and egl-4

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001294450.1	Gene:	egl-4 / 176991	WormBaseID:	WBGene00001173	Length:	783	Species:	Caenorhabditis elegans

Alignment Length:	776	Identity:	367/776 - (47%)
Similarity:	495/776 - (63%)	Gaps:	92/776 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 REREAIVSNLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLP 73
            |:::.||....|.:..|       |.|:..|.||..||:|||:|.
Worm    84 RQQQTIVEGHIKRISEL-------EGEVTTLQRECDKLRSVLEQK-------------------- 121

  Fly    74 EQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTS--ADEVRPKA 136
                                         |..|.|.|...|       |||.||.  .::::.||
Worm   122 -----------------------------AQSAASPGGQPP-------SPSPRTDQLGNDLQQKA 150

  Fly   137 -MPA----AIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRE 196
             :||    ..||..||||   .:..::....:..|.|....||.|:||:..|||||.:...|:.|
Worm   151 VLPADGVQRAKKIAVSAE---PTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIE 212

  Fly   197 LVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTA 261
            ||:.||.....||::||:|||.|..|:|.|.||..|.::|.:|.||.||...|||||||||||||
Worm   213 LVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTA 277

  Fly   262 SIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYA 326
            |::.|:: .::|||||.|||.|....|::|....:|||..|.:..||||:.::|:|||::.::|.
Worm   278 SVQALTD-VQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYD 341

  Fly   327 AGTYIIRQG---TAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTAN 388
            .|.||||||   ..||:||:|:.|.|:|||::...: |..|:|.|::||:|||:||:.|:.||||
Worm   342 GGHYIIRQGEKCLQGDAFFVINSGQVKVTQQIEGET-EPREIRVLNQGDFFGERALLGEEVRTAN 405

  Fly   389 IIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQESCRDEPK-----EQLQQE 448
            |||.:||||.|||||:||.:|||||..|| |||||:.| ||     :..|:.|.     :..::|
Worm   406 IIAQAPGVEVLTLDRESFGKLIGDLESLK-KDYGDKER-LA-----QVVREPPSPVKIVDDFREE 463

  Fly   449 FPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLS 513
            |..:.|.:::.::|||:||||||||| ..:.|:...||||.|||:|||||:|:||||:||:||:.
Worm   464 FAQVTLKNVKRLATLGVGGFGRVELV-CVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMME 527

  Fly   514 SRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGI 578
            :.:.:|.:||:||||:|:||||||.|:|||:||.|||||.|:|..|:|.:.|||:..||||.:.|
Worm   528 TSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNI 592

  Fly   579 IYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALG 643
            :||||||||.:|...||:|:|||||||::.:..||||||||||||:||||||||||:|.||||||
Worm   593 VYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALG 657

  Fly   644 ILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFP-KHISRWAVQLIKRLCRDVPSERLGYQTGG 707
            |.|.||:.|.|||.|.|||:||.|||||:|.:..| :.|.:.|..|:|:||||.|.||||..:||
Worm   658 IYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGG 722

  Fly   708 IQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNEPPDELSGWDADF 768
            :.||:||:||:||||:||.|:.|.||.:..:::|.||..||.:|.|.:.||||.||||..|
Worm   723 VNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	99/205 (48%)
		CAP_ED	185..285	CDD:237999	53/99 (54%)
		CAP_ED	304..419	CDD:237999	63/117 (54%)
		Pkinase	457..717	CDD:278497	159/260 (61%)
		STKc_cGK	463..724	CDD:270724	164/261 (63%)
		S_TK_X	719..>760	CDD:214529	19/40 (48%)
egl-4	NP_001294450.1	Crp	195..>316	CDD:223736	61/121 (50%)
		CAP_ED	201..314	CDD:237999	56/113 (50%)
		Crp	313..>427	CDD:223736	59/114 (52%)
		CAP_ED	319..437	CDD:237999	64/119 (54%)
		PTZ00263	461..779	CDD:140289	186/318 (58%)
		STKc_cGK	478..739	CDD:270724	164/261 (63%)
		S_TK_X	734..783	CDD:214529	25/48 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159813
Domainoid	1	1.000	101	1.000	Domainoid score	I4391
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4556
Inparanoid	1	1.050	675	1.000	Inparanoid score	I373
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57714
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	1	1.000	-	-		oto17920
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	1	1.100	-	-	LDO	PTHR24353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2508
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940