DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and PNPLA6

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	NP_001159583.1	Gene:	PNPLA6 / 10908	HGNCID:	16268	Length:	1375	Species:	Homo sapiens

Alignment Length:	959	Identity:	171/959 - (17%)
Similarity:	308/959 - (32%)	Gaps:	303/959 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNV-------TRNE--KAKKKLYSL 72
            :|.:.||.:  |||.:....:.||..:.....:.......|.:       ||..  :..|::.|.
Human   311 SLVRVVQII--MVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVST 373

  Fly    73 PEQCGEQESRNQNPH-----LCSSCG-MVLPTSPEFA--------------LEALSLGPLSPL-- 115
            ......:|:..:.|.     |....| .|.|||.|..              :..|..||.|..
Human   374 SATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDM 438

  Fly   116 --------------ASTSSASPSGRTSADEVRPKAMPAAIKKQGVSAESCVQSMQQSYSIPIPKY 166
                          ||..|.:...||...|  |:..||     |....|..:....:...|...|
Human   439 AYERGRISVSLQEEASGGSLAAPARTPTQE--PREQPA-----GACEYSYCEDESATGGCPFGPY 496

  Fly   167 E-KDFSD-----KQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVS 225
            : :..|.     ||::.      ..::..|.|.:...|...::|   ||..:.|:|:....|:..
Human   497 QGRQTSSIFEAAKQELA------KLMRIEDPSLLNSRVLLHHAK---AGTIIARQGDQDVSLHFV 552

  Fly   226 AAGEFAVMQQGKVLDK--------MGAGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQ 282
            ..|...|.|  :::||        ...|:..|:||:|.......::|...:
Human   553 LWGCLHVYQ--RMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRD-------------- 601

  Fly   283 IMMCTGLQRIENS--VNFLRSVP-LLMNLSEELLAKIAD-VLELEF------YAAGTYIIRQGTA 337
               ||.| ||..|  ...:|:.| ::::.:..:.|:::. |.:::|      ..||..:.|||..
Human   602 ---CTFL-RISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDR 662

  Fly   338 GDSFFLISQGNVR-VTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVECLTL 401
            .|..:::..|.:| |.|:   .|.::..:....|||..|....:....|...:.|:. ..|...|
Human   663 SDCTYIVLNGRLRSVIQR---GSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVR-DTELAKL 723

  Fly   402 DRDSF-------------------KRLIGDLCELK-------------EKDYGDESRKLAMKQAQ 434
            ...:.                   ::::|:|.:|:             ..:..:.:..||.....
Human   724 PEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLGVPPHSELTNPASNLATVAIL 788

  Fly   435 ESCRDEP--------KEQLQQEFPDLKLTDLEVVSTLGIGGFGRVE-------LVKAHHQDRVDI 484
            ..|.:.|        :..||...|.|.|....:.:.||......::       |.:.....|:.:
Human   789 PVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVL 853

  Fly   485 F---------ALKCLKK-------------------------------RHIVDTKQEE------- 502
            :         .::||::                               :.:|...:||
Human   854 YQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRT 918

  Fly   503 --------------HIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGS 553
                          |:...|. :.|.|||  .:|:..:.               ::::...||.|
Human   919 VEWLNMRSWCSGHLHLRCPRR-LFSRRSP--AKLHELYE---------------KVFSRRADRHS 965

  Fly   554 FEDNAAQFIIG-CVLQAFEYLHARGIIYRD-LKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTF 616
            .....|:.:.| .:........|||..:.. ||    .|:|.|..  ||......||      :|
Human   966 DFSRLARVLTGNTIALVLGGGGARGCSHIGVLK----ALEEAGVP--VDLVGGTSIG------SF 1018

  Fly   617 CGTPEYVAPEIILNKGHDRAVDYWALGI--LIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPK 679
            .|.  ..|.|...::...||.: ||..:  ::..:|:.|.|.::   |.|.:...:.|..:...|
Human  1019 IGA--LYAEERSASRTKQRARE-WAKSMTSVLEPVLDLTYPVTS---MFTGSAFNRSIHRVFQDK 1077

  Fly   680 HI-SRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTD 743
            .| ..|....  .:..|:.:..:          :.||  .|..|..:.:.:.:..::.|:..|.|
Human  1078 QIEDLWLPYF--NVTTDITASAM----------RVHK--DGSLWRYVRASMTLSGYLPPLCDPKD 1128

  Fly   744 VR------YFDRFPC----------------------DLNEPPDELSGW 764
            ..      |.:..|.                      ||:...|.||||
Human  1129 GHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGW 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	46/221 (21%)
		CAP_ED	185..285	CDD:237999	20/107 (19%)
		CAP_ED	304..419	CDD:237999	25/154 (16%)
		Pkinase	457..717	CDD:278497	53/332 (16%)
		STKc_cGK	463..724	CDD:270724	55/333 (17%)
		S_TK_X	719..>760	CDD:214529	9/68 (13%)
PNPLA6	NP_001159583.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CAP_ED	195..316	CDD:237999	1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..436		17/83 (20%)
		Atrophin-1	<354..502	CDD:331285	30/154 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..472		7/24 (29%)
		CAP_ED	512..622	CDD:237999	28/138 (20%)
		CAP_ED	635..743	CDD:237999	21/111 (19%)
		Pat_PNPLA6_PNPLA7	964..1269	CDD:132864	49/246 (20%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	985..990		1/4 (25%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1012..1016		0/3 (0%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1134..1136		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1306..1375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900