Protein Alignment Pkg21D and SGK2

DIOPT Version :10

• Sequence 1: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Sequence 2: NP_057360.3
• Gene: SGK2 / 10110
• HGNCID: 13900
• Length: 367
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 110/301 - (36%)
• Similarity: 175/301 - (58%)
• Gaps: 7/301 - (2%)

  Fly   450 PDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSS 514
            |:.:.||.:.:..:|.|.:|:|.|.|......  .:|:|.|:|:.|:..|::.||.:||.::|.:
Human    28 PNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGA--FYAVKVLQKKSILKKKEQSHIMAERSVLLKN 90

  Fly   515 -RSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGI 578
             |.||:..|..:|:..:.:|.:|:...|||::..|:....|.:..|:|....|..|..|||:..|
Human    91 VRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNI 155

  Fly   579 IYRDLKPENLMLDERGYVKIVDFGFAKQ-IGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWAL 642
            |||||||||::||.:|:|.:.|||..|: :.....|.||||||||:|||::..:.:|||||:|.|
Human   156 IYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCL 220

  Fly   643 GILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGG 707
            |.:::|:|:|.|||.:.|..|.|..||.  ..:..|...:..|..|::.|......:|||.:...
Human   221 GAVLYEMLHGLPPFYSQDVSQMYENILH--QPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADF 283

  Fly   708 IQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFD 748
            : :||.|.:|...:||.|..:.|.|||...:..|.|:::||
Human   284 L-EIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFD 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		STKc_cGK	463..724	CDD:270724	97/262 (37%)
		S_TK_X	719..>760	CDD:214529	11/30 (37%)
SGK2	NP_057360.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		STKc_SGK2	39..359	CDD:270754	107/290 (37%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		3/9 (33%)