DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and LOC100498055

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_002935815.2	Gene:	LOC100498055 / 100498055	-ID:	-	Length:	763	Species:	Xenopus tropicalis

Alignment Length:	795	Identity:	365/795 - (45%)
Similarity:	490/795 - (61%)	Gaps:	85/795 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTDRERE---AIVSNLTKDVQALREMVRSRESELVKLHREIHKLKSVLQ---------QTTNNLN 58
            |..|.||   ...|.|.:.|..|.|.::.|..||.:...:|.:|:..|:         |.....|
Frog    22 LFSRRREHSSGAFSKLQETVLLLEEELKQRWKELQEKDEKILQLEKELEVKVIQIDKLQDALGYN 86

  Fly    59 VTRNE---KAKKKLYSLPEQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSS 120
            ||:..   ..||||.|:..|                                     .|..:...
Frog    87 VTQTSPKGSQKKKLLSVINQ-------------------------------------GPAQNNEK 114

  Fly   121 ASPSGRTSADEVRPKAMPAAIKKQGVSAESCVQSM--QQSYSIPIPKYEKDFSDKQQIKDAIMDN 183
            |:.:.|      |.||      |:|||||...:..  ..|.:..:....||.|.|:.|..|||.|
Frog   115 AAEAHR------RQKA------KEGVSAEPTSRHYYNPSSQNPDVTCVRKDSSAKKLITGAIMSN 167

  Fly   184 DFLKNIDASQVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAF 248
            |||:.::||.||.:||.||.:..:..:.||:||..|.||||.|.|...|:|..::|.:|..|.||
Frog   168 DFLRQLEASHVRCMVDCMYERVYSKSQLVIQEGAAGNHLYVLADGLLDVIQNSRLLGQMHPGTAF 232

  Fly   249 GELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELL 313
            |||||||||.|||:::.::: :::|||||:|||.|||.:...:.:...:|||||.||.:|.||.|
Frog   233 GELAILYNCKRTATVKAVTD-SKIWVLDRQVFQNIMMSSAQAQHQEYFSFLRSVSLLKDLPEEKL 296

  Fly   314 AKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQA 378
            :||.|.||::||..|.||||:|..|::||:|::|.|.|||.: ..|.|..|::||..||||||:|
Frog   297 SKIVDCLEVDFYDKGDYIIREGEEGNTFFIIAKGKVCVTQAV-EGSQEPQEIKTLGVGDYFGEKA 360

  Fly   379 LINEDKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKE--KDY------GDESRKLAMKQA-- 433
            ||:||.|:|||||.....:||.:|||:|.:::|...||:.  ::|      .|..|:.|.:::
Frog   361 LISEDVRSANIIAEEDDTQCLVIDRDTFNQMVGTYQELQTYLREYVFQLALNDHDRRNARRKSLH 425

  Fly   434 QESCRDEPK-EQLQQEFPDLKLTD----LEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKR 493
            ....||..: .||::.......|.    |:|::|||.||||||||||...:|..  |||||:||:
Frog   426 HSMSRDNSEVNQLRELVSKFSSTSPFRYLDVITTLGTGGFGRVELVKLKDEDMT--FALKCIKKK 488

  Fly   494 HIVDTKQEEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNA 558
            |||||.|:||::.|::|:......||.||||||||.||||||||.|:|||:|::|||.|.||:..
Frog   489 HIVDTHQQEHVYWEKNILQQINCSFIIRLYRTFRDAKYVYMLLEVCLGGELWSILRDTGPFEEGT 553

  Fly   559 AQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYV 623
            |:|..||||:||:|||.|||:|||||||||:||..||:|:|||||||:||...||||||||||||
Frog   554 ARFCTGCVLEAFDYLHNRGIVYRDLKPENLLLDSEGYIKMVDFGFAKKIGPGKKTWTFCGTPEYV 618

  Fly   624 APEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQL 688
            |||||:|:|||...|||:|||||:|||.|:||||..||::.||::||||:.:.||..|.|.:..:
Frog   619 APEIIMNRGHDFGADYWSLGILIYELLTGSPPFSGTDPIKIYNMVLKGIEKVDFPHRIGRRSEDV 683

  Fly   689 IKRLCRDVPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCD 753
            |:||||..|:||||.:..||.||:|||||.||:|:||.::.|:.|..|.|...||..|||.|..:
Frog   684 IRRLCRINPAERLGNRKNGISDIRKHKWFQGFNWEGLRNRKLLSPLKREIKGITDHSYFDNFLPE 748

  Fly   754 LNEPPDELSGWDADF 768
            ..||||||||||.:|
Frog   749 SEEPPDELSGWDKNF 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	102/202 (50%)
		CAP_ED	185..285	CDD:237999	49/99 (49%)
		CAP_ED	304..419	CDD:237999	59/116 (51%)
		Pkinase	457..717	CDD:278497	165/259 (64%)
		STKc_cGK	463..724	CDD:270724	167/260 (64%)
		S_TK_X	719..>760	CDD:214529	18/40 (45%)
LOC100498055	XP_002935815.2	CAP_ED	169..278	CDD:237999	51/109 (47%)
		CAP_ED	287..402	CDD:237999	59/115 (51%)
		STKc_cGK	460..719	CDD:270724	167/260 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57714
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2508
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960