DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkg21D and prkg2

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_002934043.3	Gene:	prkg2 / 100497736	XenbaseID:	XB-GENE-951552	Length:	787	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	357/777 - (45%)
Similarity:	483/777 - (62%)	Gaps:	60/777 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 REREAIVSNLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLP 73
            :.:|.|...|.:.::...:::.....||.....:::||: |:.||.|.::.|
Frog    54 KNKEQIFQELQEQIKKQNQVIEEMAEELQNKCVQLNKLQ-VVVQTQNGISTT------------- 104

  Fly    74 EQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAMP 138
                        |.|    ..:|..||...|.||   |...|..:...:.||..|....|..|
Frog   105 ------------PDL----HKMLQPSPTKTLHAL---PTKSLKGSPLKTFSGLFSNSNKRKGA-- 148

  Fly   139 AAIKKQGVSAESCVQ---SMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDS 200
                |:|||||...:   .....:|....:..|:.|:|..|.||:..|.|:|.:|..|::::|:.
Frog   149 ----KEGVSAEPTSRYDGGDHPRFSFEKARVRKNTSEKILISDALNKNQFMKRMDHHQIQDMVEC 209

  Fly   201 MYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRV 265
            ||.:....|||:||:||.|:.::|.|.|:..|.|:.|:|..:.....|||||||||||||||::.
Frog   210 MYERIYLQGEFIIRQGEPGSQIFVLADGKAEVFQENKLLTSIPVWTTFGELAILYNCTRTASVKA 274

  Fly   266 LSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTY 330
            :: ..|.|.|||.|||.||..|...:.|..::||:|||||..|.|..|.||||.||||||....|
Frog   275 IT-GVRTWTLDREVFQNIMRKTAQSKHEEYLSFLKSVPLLKELPEHKLMKIADCLELEFYEMDDY 338

  Fly   331 IIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPG 395
            |||:|..|.:||:||:|.|:|||. |....|...::.|.:||||||:|||::|.|:|||:|....
Frog   339 IIREGEEGSTFFIISKGKVKVTQS-TEGYKEPQYIKFLEKGDYFGEKALISDDVRSANILAYGDR 402

  Fly   396 VECLTLDRDSFKRLIGDLCELKEKDYG-------DESRKLAMKQAQE------SCRDEPKEQLQQ 447
            ||||.:||::|.:.:|...||.:...|       |:.|:.|.....|      |......:|...
Frog   403 VECLVMDRETFNKTVGTYEELMKCLEGYVANLTLDDERRHAKSPVNERHLRAVSMELNKMKQTLA 467

  Fly   448 EFPDLK-LTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIM 511
            .||... ..:||:|:|||:||||||||||..:::.|  |||||:|||||||.:|:|||.||::|:
Frog   468 RFPSASPFENLEIVTTLGVGGFGRVELVKVKNENLV--FALKCIKKRHIVDNRQQEHIHSEKNIL 530

  Fly   512 LSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHAR 576
            ..:.||||.:||.||:|.||||||||||:|||:|::|||||||::..|:|..|||.:||||||.:
Frog   531 EEACSPFIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQK 595

  Fly   577 GIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWA 641
            |::|||||||||:||..||||:|||||||:|....|||||||||||||||:||||||..:||:|:
Frog   596 GVLYRDLKPENLLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWS 660

  Fly   642 LGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTG 706
            ||||::|||.|:|||:.||.|..|||||:||:.|.|.|:|::....||:||||:.|:||||....
Frog   661 LGILLYELLTGSPPFTGPDQMIIYNLILQGIEKIEFYKNITKRPEDLIRRLCRENPAERLGNMKN 725

  Fly   707 GIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNEPPDELSGWDADF 768
            ||.|||||:||.||:|:||.::.|..|....:..|||..|||.:|.|...||||:||||.||
Frog   726 GIADIKKHRWFNGFNWEGLNTRSLPSPLKPELEGPTDHSYFDSYPPDEEIPPDEVSGWDQDF 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	98/202 (49%)
		CAP_ED	185..285	CDD:237999	46/99 (46%)
		CAP_ED	304..419	CDD:237999	58/114 (51%)
		Pkinase	457..717	CDD:278497	168/259 (65%)
		STKc_cGK	463..724	CDD:270724	169/260 (65%)
		S_TK_X	719..>760	CDD:214529	17/40 (43%)
prkg2	XP_002934043.3	CAP_ED	194..303	CDD:237999	49/109 (45%)
		CAP_ED	312..427	CDD:237999	58/115 (50%)
		STKc_cGK	484..743	CDD:270724	169/260 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8060
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4556
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57714
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930