DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkg21D and prkar2a

DIOPT Version :9

Sequence 1:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster
Sequence 2:	XP_002933104.1	Gene:	prkar2a / 100486265	XenbaseID:	XB-GENE-982783	Length:	404	Species:	Xenopus tropicalis

Alignment Length:	383	Identity:	105/383 - (27%)
Similarity:	177/383 - (46%)	Gaps:	41/383 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PTSPEFAL------------EALSLGPLSPLA----------STSSASPSGRTSADEVRPKAMPA 139
            |...|||:            :....|.|.|.|          .|.|.........|:......|.
Frog    26 PDLVEFAIQYFTRLKEKQLQDGAGAGSLRPHARVVNFDGEPMQTESNGDEEEDEEDDDDSDFEPP 90

  Fly   140 AIKKQGVSAESCVQSM--QQSYSIPIPKYEKDFSDKQ--QIKDAIMDNDFLKNIDASQVRELVDS 200
            .|.:.......|.::.  .:......|:..:..:|:|  ::::|..|....||:|..|:.:::|:
Frog    91 VINRYSRRVSVCAEAYNPDEEDEDTEPRVVRPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDA 155

  Fly   201 MYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVM----QQGKVLDKMGAGKAFGELAILYNCTRTA 261
            |:...:...|.||.:|:.|.:.||...|::.:.    .|.:.:.:.....:|||||::||..|.|
Frog   156 MFEMRVKPQEHVIDQGDDGDNFYVVERGQYDIFVERDGQSRCVGRYDNHGSFGELALMYNTPRAA 220

  Fly   262 SIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLL--MNLSEELLAKIADVLELEF 324
            :|...||.| :|.|||..|::|::....::.:....|:.|||:|  :.|||.:  ||.||:....
Frog   221 TIVATSEGA-LWGLDRVTFRRIILKNNAKKRKTYEIFIESVPVLKFLELSERM--KIVDVIAARV 282

  Fly   325 YAAGTYIIRQGTAGDSFFLISQGNVRVTQK-LTPT---SPEETELRTLSRGDYFGEQALINEDKR 385
            |..|..||.||...|.||::..|.|::..| .|.|   |.:|.|:.....|.||||.||:....|
Frog   283 YKDGDRIIAQGDKADCFFIVESGEVKIMMKSKTKTGQESNQEVEIARCKSGQYFGELALVTNKPR 347

  Fly   386 TANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGD-ESRKLAMKQAQESCRDEPK 442
            .|:..|:. .|:||.:|..:|:||:|...::.:::... |.:.:|:..:....||..|
Frog   348 AASAYAVG-DVKCLIMDVQAFERLLGPCMDIMKRNITHYEEQLVALFGSSMDLRDPGK 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	70/212 (33%)
		CAP_ED	185..285	CDD:237999	34/103 (33%)
		CAP_ED	304..419	CDD:237999	43/120 (36%)
		Pkinase	457..717	CDD:278497
		STKc_cGK	463..724	CDD:270724
		S_TK_X	719..>760	CDD:214529
prkar2a	XP_002933104.1	DD_RIIalpha_PKA	3..43	CDD:213050	4/16 (25%)
		CAP_ED	140..253	CDD:237999	34/113 (30%)
		CAP_ED	262..382	CDD:237999	43/122 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910