DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3544 and XKS1

DIOPT Version :9

Sequence 1:	NP_001259842.1	Gene:	CG3544 / 33252	FlyBaseID:	FBgn0031279	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_011710.3	Gene:	XKS1 / 853108	SGDID:	S000003426	Length:	600	Species:	Saccharomyces cerevisiae

Alignment Length:	437	Identity:	135/437 - (30%)
Similarity:	235/437 - (53%)	Gaps:	25/437 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YLGLHLGTQLFRALILDSKLNVTYVAQIRYDVDLPEFKTTNGILSDGGPGEFLANPV-MWVKALD 77
            |||..|.||..:.|.::..|.:.:...:.::.|||.:.|..|:...   |:.:..|| ||::|||
Yeast    23 YLGFDLSTQQLKCLAINQDLKIVHSETVEFEKDLPHYHTKKGVYIH---GDTIECPVAMWLEALD 84

  Fly    78 MLMDCLVKQGADMHTVVSIAGAAQQHGCVFWSELGLRRLCNLNVNLR---LHEQITESAFELTRT 139
            :::....:....::.|::::|:.||||.|:||......|..||....   || .::..||.....
Yeast    85 LVLSKYREAKFPLNKVMAVSGSCQQHGSVYWSSQAESLLEQLNKKPEKDLLH-YVSSVAFARQTA 148

  Fly   140 PTWRDSSTDVQVREMEHTVGGPAELSKITGSRAYTRFTGPQIRKVYTQCPEQYERTSRISLISSF 204
            |.|:|.||..|.:|.|..:|||.:::::|||||:.|||||||.|:....||.||:|..|||:|:|
Yeast   149 PNWQDHSTAKQCQEFEECIGGPEKMAQLTGSRAHFRFTGPQILKIAQLEPEAYEKTKTISLVSNF 213

  Fly   205 LASLLIGGIASIDYSDGSGMNLLDIRKKKWSAACL---DACAPD--LARRLMKPIPSSRLQGRIG 264
            |.|:|:|.:..::.:|..||||.|||::|:|...|   |:.:.|  :.::||:....:.:.|.|.
Yeast   214 LTSILVGHLVELEEADACGMNLYDIRERKFSDELLHLIDSSSKDKTIRQKLMRAPMKNLIAGTIC 278

  Fly   265 DYYVKRWNFRPDCMVVASTGSKASELAGLLVENDFLMLSLDTSDVVVMPLKKAPRLEDGHVMCHP 329
            .|:::::.|..:|.|...||...:.:..|.:..:.:::||.||..|::...|.....:.|:..||
Yeast   279 KYFIEKYGFNTNCKVSPMTGDNLATICSLPLRKNDVLVSLGTSTTVLLVTDKYHPSPNYHLFIHP 343

  Fly   330 TRRDEYMGLLCFQNGGLTRKAICEDV---------AGGSWRHFYE-MLDATPSGNNGNVAVHFRD 384
            |..:.|||::|:.||.|.|:.|.:::         ....|..|.: :||.:.|..| .:.|:|..
Yeast   344 TLPNHYMGMICYCNGSLARERIRDELNKERENNYEKTNDWTLFNQAVLDDSESSEN-ELGVYFPL 407

  Fly   385 REIIPTAKGTLRWDAHISPMSAECIRGLHRFSTPEIEVRALIEGQIM 431
            .||:|:.| .:......:|.:....|.:.:|.....:.:.::|.|.:
Yeast   408 GEIVPSVK-AINKRVIFNPKTGMIEREVAKFKDKRHDAKNIVESQAL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3544	NP_001259842.1	FGGY_D-XK_euk	13..493	CDD:212660	135/437 (31%)
CG3544	NP_001259842.1	XylB	15..494	CDD:273550	134/436 (31%)
XKS1	NP_011710.3	FGGY_D-XK_euk	22..545	CDD:212660	135/437 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342056
Domainoid	1	1.000	124	1.000	Domainoid score	I1202
eggNOG	1	0.900	-	-		E1_COG1070
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I621
Isobase	1	0.950	-	0	Normalized mean entropy	S1469
OMA	1	1.010	-	-		QHG56396
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		otm46806
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3110
TreeFam	1	0.960	-	-
	13	12.810