DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3544 and Xylb

DIOPT Version :9

Sequence 1:	NP_001259842.1	Gene:	CG3544 / 33252	FlyBaseID:	FBgn0031279	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001028381.1	Gene:	Xylb / 102448	MGIID:	2142985	Length:	551	Species:	Mus musculus

Alignment Length:	555	Identity:	224/555 - (40%)
Similarity:	313/555 - (56%)	Gaps:	44/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGLHLGTQLFRALILDSKLNVTYVAQIRYDVDLPEFKTTNGI------LSDGGPGEFLANPV-MW 72
            ||....||..:.:.:|::|||.|...:.:|.|||||.|..|:      |:       :.:|| ||
Mouse    26 LGWDFSTQQVKVVAVDAELNVFYEDSVHFDRDLPEFGTQGGVHVHKDRLT-------VTSPVLMW 83

  Fly    73 VKALDMLMDCLVKQGADMHTVVSIAGAAQQHGCVFWSELGLRRLCNLNVNLRLHEQITESAFELT 137
            |:|||:::..:...|.|...|::::||.||||.|:|.......|.:|:..|.||:|: :|.|.::
Mouse    84 VQALDLILGKMKSSGFDFSQVLALSGAGQQHGSVYWKTGASLALSSLSPALPLHQQL-QSCFSIS 147

  Fly   138 RTPTWRDSSTDVQVREMEHTVGGPAELSKITGSRAYTRFTGPQIRKVYTQCPEQYERTSRISLIS 202
            ..|.|.||||..|..::|..|||...||.:||||||.||||.||.|::.:.||.|..:.||||:|
Mouse   148 DCPIWMDSSTTAQCHQLEAAVGGAQALSCLTGSRAYERFTGNQIAKLFQKNPEAYSHSERISLVS 212

  Fly   203 SFLASLLIGGIASIDYSDGSGMNLLDIRKKKWSAACLDACAPDLARRLMKPIPSSRLQGRIGDYY 267
            ||.|||.:||.:.||||||||||||.|::|.||.||||.|||.|..:|..|:||..:.|.|..||
Mouse   213 SFAASLFLGGYSPIDYSDGSGMNLLQIQEKVWSQACLDVCAPHLEEKLGSPVPSCSVVGTISSYY 277

  Fly   268 VKRWNFRPDCMVVASTGSKASELAGLLVENDFLMLSLDTSDVVVMPLKK-APRLEDGHVMCHPTR 331
            |:|:.|.|.|.|||.:|...:.|||:.:|...:.:||.|||.:.:.|:| .|.|| ||:.|:|..
Mouse   278 VQRYGFPPGCKVVAFSGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQKPMPALE-GHIFCNPVD 341

  Fly   332 RDEYMGLLCFQNGGLTRKAICEDVAGGSWRHFYEMLDATPSGNNGNVAVHFRDREIIPTAKGTLR 396
            ...||.||||:||.|.|:.|.::.|..||..|.:.|.:|..|||||:..:|...||.|...|..|
Mouse   342 PQHYMALLCFKNGSLMREKIRDESASCSWNKFSKALKSTAMGNNGNLGFYFDVMEITPEIIGRHR 406

  Fly   397 WDAHISPMSAECIRGLHRFSTPEIEVRALIEGQIMHHWSIAHEMGFHHTPNTKIIVVGEDSRCQS 461
            ::|....:||         ...::|:|||||||.|.....|..:|:...|.|||:..|..|..:.
Mouse   407 FNAENMEVSA---------FPGDVEIRALIEGQFMAKRIHAEGLGYRVMPKTKILATGGASHNKD 462

  Fly   462 VLQIVADIFNAPVYQRTGVEVSLLGCAFRARYAFYEHRESACNCHSCMMPTGRRTRLSFDEFFRD 526
            :||::||:|.||||.......:.:|.|:||             .|.....||    ::|.|..:.
Mouse   463 ILQVLADVFGAPVYVIDTTSSACVGSAYRA-------------FHGLAGGTG----VAFSEVVKS 510

  Fly   527 VPSGLKLAAEPTPGCDKIYKPLIERCSQICQLLAS 561
            .|.. .|||.|.||..::|..|:.|.|.:.|.:.|
Mouse   511 APQP-SLAATPNPGASQVYAALLPRYSALEQRILS 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3544	NP_001259842.1	FGGY_D-XK_euk	13..493	CDD:212660	206/485 (42%)
CG3544	NP_001259842.1	XylB	15..494	CDD:273550	206/486 (42%)
Xylb	NP_001028381.1	FGGY_D-XK_euk	24..494	CDD:212660	206/498 (41%)
Xylb	NP_001028381.1	PLN02669	26..549	CDD:178274	224/555 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833647
Domainoid	1	1.000	161	1.000	Domainoid score	I3994
eggNOG	1	0.900	-	-		E1_COG1070
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1643
Isobase	1	0.950	-	0	Normalized mean entropy	S1469
OMA	1	1.010	-	-		QHG56396
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004391
OrthoInspector	1	1.000	-	-		otm43432
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.810