DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and GABBR2

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:NP_005449.5 Gene:GABBR2 / 9568 HGNCID:4507 Length:941 Species:Homo sapiens


Alignment Length:953 Identity:283/953 - (29%)
Similarity:447/953 - (46%) Gaps:160/953 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 LLGLFELSTSRGPRPDGLSELGAATMAVEHINRKRLLPGYTLELVTNDTQCDPGVGVDRFFHAIY 219
            ::||..|:........|...|.|..:|:|.|..:.||..|.|:|...||:||...|:..|:.||.
Human    58 IMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIK 122

  Fly   220 TQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPA 284
            ..|:  .:|:.|..|..||..:|:.:..||:||:||.:|:|.|:|::::|||:|||..|::.|||
Human   123 YGPN--HLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPA 185

  Fly   285 RIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFA---ATDFKEQLLLLRET 346
            .:..::.:.|..|.|.:|:.:..|...|:|...|...:|..:.|.:|:   .|..|:    |:..
Human   186 ILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKK----LKGN 246

  Fly   347 DTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRT-----ACSNHELQLAV 406
            |.|||:|.|.|.:|.::.|.||...|:|:.|.||:.......||....|     .|....|..|:
Human   247 DVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAM 311

  Fly   407 ENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRR 471
            |..|           .|.:..|::....:...|...|:..:      |.:              :
Human   312 EGYI-----------GVDFEPLSSKQIKTISGKTPQQYERE------YNN--------------K 345

  Fly   472 RRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEF 536
            |.|||        |.....||   ||.:|.||..|:.|.|....:....::..|:||...:....
Human   346 RSGVG--------PSKFHGYA---YDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRII 399

  Fly   537 LQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVKWHSG 601
            |..|.:.:|.||:|.|.|...:|:||..|.|.|......|..|....|.|:....   .:::...
Human   400 LNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIIND---TIRFQGS 461

  Fly   602 QVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVG 666
            :.|..|.:...::..|:...:..::.|:.:|:.:|.|||.||:..|..|.||:|||.::|:..:|
Human   462 EPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILG 526

  Fly   667 CIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVF 731
            .:..||::.|.|||.|.:  :|.:|.|:||.|.::|:.|::.|||:|||||:|||.||...  ..
Human   527 GMLSYASIFLFGLDGSFV--SEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNV--KM 587

  Fly   732 KDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQH 796
            |.|:::|.:|:::|||:||:|..::..|...||:.|.:...::|.....|.:..:|.:|.|.:.|
Human   588 KKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTH 652

  Fly   797 TQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERV 861
            ...||.::|||||||::.|.::|||||:|.|||||||:|||:|||:|.|...|...::.|..::.
Human   653 MTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQP 717

  Fly   862 TLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQY 926
            .:.|..:..:|:..:|.||||:|:|||                    :...|........|..|:
Human   718 NVQFCIVALVIIFCSTITLCLVFVPKL--------------------ITLRTNPDAATQNRRFQF 762

  Fly   927 RVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTT--SSSTSLLTG----GGHLKPELT--- 982
               .||:  |||    |::            |:||.|:  .:|||.|.|    ...|:.::|   
Human   763 ---TQNQ--KKE----DSK------------TSTSVTSVNQASTSRLEGLQSENHRLRMKITELD 806

  Fly   983 -----VTSGISQTPAASK-----------------NRTPSISG---ILPNLLLSVLPPVIPRASW 1022
                 ||..:..||..:.                 |.|.|..|   ||.|.|     ...|:..|
Human   807 KDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHL-----DQNPQLQW 866

  Fly  1023 PSAEYMQ--------------IPMRRSVTFASQPQLEEACLPA 1051
            .:.|..:              |..|.|:..   |.|..|.||:
Human   867 NTTEPSRTCKDPIEDINSPEHIQRRLSLQL---PILHHAYLPS 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 128/451 (28%)
7tmC_GABA-B-like 621..892 CDD:320175 109/270 (40%)
TM helix 1 621..645 CDD:320175 8/23 (35%)
TM helix 2 657..678 CDD:320175 6/20 (30%)
TM helix 3 696..720 CDD:320175 12/23 (52%)
TM helix 4 741..761 CDD:320175 8/19 (42%)
TM helix 5 797..823 CDD:320175 13/25 (52%)
TM helix 6 832..855 CDD:320175 11/22 (50%)
TM helix 7 862..887 CDD:320175 8/24 (33%)
GABBR2NP_005449.5 PBP1_GABAb_receptor 58..460 CDD:380589 128/452 (28%)
7tmC_GABA-B-R2 480..749 CDD:320421 109/292 (37%)
TM helix 1 480..505 CDD:320421 8/24 (33%)
TM helix 2 517..538 CDD:320421 6/20 (30%)
TM helix 3 554..578 CDD:320421 12/23 (52%)
TM helix 4 597..617 CDD:320421 8/19 (42%)
TM helix 5 653..679 CDD:320421 13/25 (52%)
TM helix 6 688..711 CDD:320421 11/22 (50%)
TM helix 7 718..743 CDD:320421 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..790 14/44 (32%)
GBR2_CC 779..817 CDD:465774 9/37 (24%)

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